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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.

About

Agathe Subtil is directrice de recherche at the Centre National de la Recherche Scientifique (CNRS). After a PhD on endocytosis of membrane receptors under the supervision of Alice Dautry-Varsat at the Institut Pasteur in Paris, she joined the lab headed by Tim McGraw in the Weill Cornell Medical College in New York to study the traffic of glucose transporters. She was recruited by the CNRS in 1999 and started applying her cell biology training to the study of the interactions between an obligate intracellular bacterium, Chlamydia, and its eukaryotic host. The recent activities of her laboratory, at the Institut Pasteur, focus on the effects of infection on the host cell intracellular compartments and nucleus.

Projects

Project
Ongoing
2 Members

DNA damage during Chlamydia infection

Agathe Subtil (PI)

Epidemiological studies show that genital infections with the intracellular bacteria Chlamydia trachomatis increase the risk of cervical cancer, but the underlying mechanisms are still elusive. C. trachomatis infection causes DNA damage in the host […]
Project
Ongoing
6 Members

TheraEPI

Paola Arimondo (PI)

A common phenomenon in most microbial infections is the attenuation of the host’s immediate immune response, allowing for long-term colonization. We and others have shown that many pathogens achieve this by manipulating the epigenetic […]
Project
Ongoing
2 Members

Chlamydia and the emergence of Plants

Agathe Subtil (PI)

The idea that Chlamydiae have been important in the evolutionary history of Archaeplastida (Plants) was first hinted at by the discovery that a surprisingly large number of genes in the Chlamydia genomes have closely-related […]
Project
Ongoing
5 Members

Building the parasitophorous vacuole

Agathe Subtil (PI)

The membrane of the inclusion is key for the regulation of the exchanges between the bacteria and the host. We study its biogenesis and how metabolites from the host are transported to the lumen […]
Project
Completed
3 Members

ERC-2011-StG NUChLEAR

Agathe Subtil (PI)

The project aimed at understanding to what extent Chlamydia infection affects nuclear activities of the host, as well as to study the function of non-nuclear targeted effector proteins.

Publications

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