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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.

About

My interest is to investigate the pathogenesis of infectious diseases induced by bacteria in respiratory and reproductive systems. Particularly, I focus on pathogen-host interaction and try to understand the mechanisms by which host responses to bacterial infection inducing inflammation and the bacterium evades the host clearance. I am currently studying the innate immune system against Chlamydia trachomatis infection in female genital tract (FGT) using epithelia (cell lines and primary epithelial cells isolated from animal and patient) and small animal models. The aim is to identify host receptor(s) in sensing chlamydia and modulating immune response, and to decipher the role of ISG15 in chlamydia infection process. I also make efforts in developing the new vaccine against C. trachomatis infection in FGT.

Projects

Project
Ongoing
2 Members

Chlamydia infection and infertility

Yongzheng Wu (PI)

The asyptomatic infection by Chlamydia leads to severe complications such as infertility and ectopic pregnancy. We will attempt to understand how chlamydia infection induces either functional or organic infertility in female genital tract and […]
Project
Ongoing
2 Members

Innate immune response to C. trachomatis infection in the female genital tract

Yongzheng Wu (PI)

Chlamydia trachomatis  is the most common bacterial cause of sexually transmitted infection and is particularly prevalent in the young population. C. trachomatis  is an obligate intracellular bacterium infecting primarily epithelial cells of the genital […]

Publications

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