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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.
Starting Date
18
May 2015
Status
Ongoing
Members
5
Structures
1

About

One of our important discoveries was the identification of a bacterial protein translocated into the host nucleus upon infection (Pennini et al, 2010). This protein, which we called NUE (NUclear Effector), shows histone methyl transferase activity. We are currently investigating at which site and to which extent NUE’s activity modifies the chromatin during infection, and the consequences for the host gene expression. We have also undertaken the identification of other chlamydial nuclear effectors and their functional study. Along this line, the recent discovery of methods to stably transform chlamydiae opened novel strategies of research and we recently obtained our first stably transformed cell line expressing epitope-tagged NUE. We are currently developing plasmids to perform random and targeted mutagenesis in C. trachomatis.  

image012.png

Detection of the chlamydial protein NUE in nuclear fraction (nu) over the course of infection. PARP1 is a nuclear protein and β-tubulin a cytosolic (cyt) protein. In contrast to NUE, the bacterial protein Ef-TU remains associated to the cytosolic fraction  (from Pennini et al 2010).

Fundings