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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
14
Dec 2023
Keywords
3 Keywords
Status
Ongoing
Members
2
Structures
2

About

Epidemiological studies show that genital infections with the intracellular bacteria Chlamydia trachomatis increase the risk of cervical cancer, but the underlying mechanisms are still elusive. C. trachomatis infection causes DNA damage in the host cells, which could favor cellular transformation if these cells survive the infection and multiply. This project aims at exploring, at a deep mechanistic level, the causal link between C. trachomatis and DNA damage in the host, and at investigating the long-term consequences of the damages.

Fundings