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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.

About

Agathe Subtil is directrice de recherche at the Centre National de la Recherche Scientifique (CNRS). After a PhD on endocytosis of membrane receptors under the supervision of Alice Dautry-Varsat at the Institut Pasteur in Paris, she joined the lab headed by Tim McGraw in the Weill Cornell Medical College in New York to study the traffic of glucose transporters. She was recruited by the CNRS in 1999 and started applying her cell biology training to the study of the interactions between an obligate intracellular bacterium, Chlamydia, and its eukaryotic host. The recent activities of her laboratory, at the Institut Pasteur, focus on the effects of infection on the host cell intracellular compartments and nucleus.

Projects

Project
Ongoing
6 Members

TheraEPI

Paola Arimondo (PI)

A common phenomenon in most microbial infections is the attenuation of the host’s immediate immune response, allowing for long-term colonization. We and others have shown that many pathogens achieve this by manipulating the epigenetic […]
Project
Ongoing
2 Members

Chlamydia and the emergence of Plants

Agathe Subtil (PI)

The idea that Chlamydiae have been important in the evolutionary history of Archaeplastida (Plants) was first hinted at by the discovery that a surprisingly large number of genes in the Chlamydia genomes have closely-related […]
Project
Ongoing
7 Members

Intracellular traffic

Agathe Subtil (PI)

Early steps of infection We have observed that chlamydia invasion of a host cell triggers a transient ubiquitination at the entry sites. Deubiquitination follows very rapidly (20 min post infection). We have identified a […]
Project
Ongoing
6 Members

ERC-2011-StG NUChLEAR

Agathe Subtil (PI)

One of our important discoveries was the identification of a bacterial protein translocated into the host nucleus upon infection (Pennini et al, 2010). This protein, which we called NUE (NUclear Effector), shows histone methyl […]

Publications

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