Agathe Subtil is directrice de recherche at the Centre National de la Recherche Scientifique (CNRS). After a PhD on endocytosis of membrane receptors under the supervision of Alice Dautry-Varsat at the Institut Pasteur in Paris, she joined the lab headed by Tim McGraw in the Weill Cornell Medical College in New York to study the traffic of glucose transporters. She was recruited by the CNRS in 1999 and started applying her cell biology training to the study of the interactions between an obligate intracellular bacterium, Chlamydia, and its eukaryotic host. The recent activities of her laboratory, at the Institut Pasteur, focus on the effects of infection on the host cell intracellular compartments and nucleus.
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2021A Protein-Engineered, Enhanced Yeast Display Platform for Rapid Evolution of Challenging Targets., ACS Synth Biol 2021 Dec; 10(12): 3445-3460.
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2021ATG16L1 functions in cell homeostasis beyond autophagy., FEBS J 2022 Apr; 289(7): 1779-1800.
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2021Primary ectocervical epithelial cells display lower permissivity to Chlamydia trachomatis than HeLa cells and a globally higher pro-inflammatory profile., Sci Rep 2021 03; 11(1): 5848.
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2020The Chlamydia effector CT622/TaiP targets a nonautophagy related function of ATG16L1., Proc Natl Acad Sci U S A 2020 10; 117(43): 26784-26794.
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2020Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells., EMBO J 2020 04; 39(8): e102166.
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2020Chlamydia-induced curvature of the host-cell plasma membrane is required for infection, Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2634-2644.
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2019Make It a Sweet Home: Responses of to the Challenges of an Intravacuolar Lifestyle, Microbiol Spectr 2019 03;7(2).
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2018The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Infectivity and Growth, Front Cell Infect Microbiol 2018;8:145.
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2017Tracking Proteins Secreted by Bacteria: What’s in the Toolbox?, Front Cell Infect Microbiol 2017;7:221.
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2017Biotic Host-Pathogen Interactions As Major Drivers of Plastid Endosymbiosis, Trends Plant Sci. 2017 Jan;.
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