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Veterinary
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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
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Guillaume Bouvier

© Charles Dauguet

Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.

Member: Head of Structure

Asier Sáez-Cirión

• Viral reservoirs and immune control

Laboratory: Viral reservoirs and immune control

Scientific Fields

Diseases

Organisms

Applications

Technique

Scientific Fields

Diseases

AIDS
Infectious diseases

Organisms & Organs

Application

Immunotherapy
Prevention and treatment of in

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106 Publications

@asiersc.bsky.social (March 13, 2025, 11:16 pm)

Damso & Sidaction 🔥 GRAND SOLEIL c'est disponible maintenant sur toutes les plateformes !

About

Dr Sáez-Cirión received his PhD in Science in 2001 from the University of the Basque Country, Leioa, Spain. He joined the Institut Pasteur in Paris as a Postdoc in 2003 after a first postdoctoral period at the FDA-CBER in Bethesda. He leads now the Viral Reservoirs and Immune Control Unit. His research is currently focused in understanding (i) the mechanisms underlying control of HIV infection in natural HIV controllers and post-treatment controllers in remission of HIV infection after interruption of antiretroviral treatment; (ii) the factors associated with the establishment of HIV reservoirs and devising new approaches to tackle them.

Courses

HIV Science MOOC

In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […]

HIV, Inflammation and Viral Persistences

Michaela Muller-Trutwin

Asier Sáez-Cirión

Aurelio Orta-Resendiz

2023-11-14 09:00:00 2024-01-31 22:00:00 Europe/Paris HIV Science MOOC In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […] Add to Calendar

Projects

Humoral immunity in HIV-1 post-treatment controllers

Hugo Mouquet (PI)

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers HIV-1 post-treatment controllers (PTC) are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control […]

ANRS-12414-PediacamNeg

Florence Buseyne (PI)

The ANRS 12225-Pediacam study is coordinated by Mr. Tejiokem at the Center Pasteur in Cameroon. Since 2007, the project has included children exposed or infected with HIV-1 and a group of unexposed and uninfected […]

Archive of the Group for AIDS Research

Lisa Chakrabarti (PI)

This page contains the list of past meetings held by the Group for AIDS Research (Groupe de Réflexion SIDA) of the Pasteur Institute since 2014. The list of previous meetings held since 2002 can […]

Group for AIDS Research

Nicoletta Casartelli (PI)

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. […]

ICISTEM-International Collaboration to guide and investigate the potential for HIV cure by Stem Cell Transplantation

Javier Martinez-Picado (PI)

ICISTEM is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders. The ICIISTEM consortium is composed of an expert European […]

Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)

Florence Buseyne (PI)

A collaborative study with members of Pasteur Institute (A. Saez-Cirion, D. Scott-Algara), french perinatal cohort (ANRS CO10; J. Warszawsky) and 10 hospitals from Paris Area (Principal investigator, P. Frange). The study has included 76 […]

Natural Control of HIV-1 Infection

Asier Sáez-Cirión (PI)

HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]

Role of CD8 T cells responses in the control of HIV-2 infection-ANRS Immunovir2

Asier Sáez-Cirión (PI)

The number of persons living with HIV-1 is around 35 million while roughly one million persons are living with HIV-2, with a decreasing prevalence. Both HIV-1 and HIV-2 are associated with AIDS, however most HIV-2 […]

Former Teams

Viral reservoirs and immune control

HIV, Inflammation and Viral Persistences

CV

RESEARCH POSITIONS

2023-current	Associate Professor and Head of the Viral Reservoirs and Immune Control Unit, Institut Pasteur, Paris, France.
2018-2022	Associate Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France.
2014-2017	Assistant Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France.
2010-2014	Assistant Professor in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.
2007-2009	Senior Scientist in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.
2003-2007	Postdoctoral position in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. Research advisor: Dr. Gianfranco Pancino. Project: Mechanism of resistance to HIV-1 infection in human primary cells.
2002-2003	Postdoctoral position in the Division of Viral Products, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Bethesda MD, USA. Research advisor: Dr. Carol D. Weiss. Project: Rational approaches to block HIV entry.
1998-2001	PhD student in the Unidad de Biofisica (CSIC-UPV/EHU), Department of Biochemistry, University of the Basque Country, Leioa, Spain. Research advisor: Prof. J.L. Nieva. Project: Mechanisms of virus-induced membrane fusion.
1995-1998	Undergraduate Student in the Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain. Research advisors: Prof. A. Alonso and Prof. E. A. Rivas. Projects: Effects of lipids in membrane fusion and Effects of surfactants in the different phases of lipids on model membranes.

ACADEMIC QUALIFICATION

2013	HDR in Life Sciences, Université Pierre et Marie Curie, Paris VI, Paris, France.
2001	PhD in Biochemistry and Molecular Biology, University of the Basque Country, Leioa, Spain. “Membrane interacting domains in virus and prions”. Suma Cum Laude.
2000	MSc degree, in Biochemistry. University of the Basque Country, Leioa, Spain.
1998	Graduated in Biochemistry, University of the Basque Country, Leioa, Spain.

SOME ADDITIONAL PROFESSIONAL RESPONSABILITIES

2017-present		President of Scientific and Medical Committee of SIDACTION
2014-present		Coordinator of the ANRS RHIVIERA consortium on HIV remission
2013-present		Coordinator of the ANRS International Post-Treatment Controllers cohort
2013-present		Member of the Scientific and Medical Committee of SIDACTION
2012-present		Member of the Scientific Committee of CO6 ANRS PRIMO cohort
2012-present		Member of Institut Pasteur’s Groupe de Réflexion sur le SIDA (GRS)
2012-present		Member of the Steering Committee of CO21 ANRS CODEX cohort
2011-2017		Co-president of the ANRS coordinated action AC32 “HIV reservoirs”
2010-2017		Elected Member of Institut Pasteur’s Virology Department Council

Publications

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Published on: 11 May 2015 • Modified on: 28 Mar 2025