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© Michaela Muller-Trutwin
HIV

About

Beatrice Jacquelin joined Michaela Müller-Trutwin’s group at Institut Pasteur as a research engineer in 2004. Throughout the years of her graduate (1998-2001) and postdoctoral (2002-2004) training that she performed at The Scripps Research Institute (USA), at the UMR 5533 CNRS (Bordeaux) and at the Genopole of Evry (CEA), she developed a strong scientific research experience in gene regulation that she applied in the field of hemostasis and hematopoiesis. A good way to get new insights in gene regulations is to study them in pathologic situations. She therefore started to study the mechanisms responsible for aberrant T cell activation leading to AIDS using the SIV-infection models at Institut Pasteur. The focus of her work is now on factors of either susceptibility to SIV-induced inflammation or factors that allow the control of this inflammation. Their identification might deliver the missing key elements for the understanding of how HIV induces AIDS and also novel targets for anti-inflammatory therapies in HIV-infected patients. In parallel, Beatrice is also involved in the Ebola task force program (Pierre Lafaye’s Work Package) to develop an easy-to-use, cheap, fast, accessible and easily disposable test for on-the-field, point-of-care diagnostics.

Projects

CV

Education

1998-2001

Ph.D. in Biology and Pharmacology of Hemostasis and Vessels / University Paris Diderot (B2T), Paris 7

1997

Master II (DEA) in Biology and Pharmacology of Hemostasis and Vessels / University Paris 7 (B2T)

1991-1996

Degree in Biochemistry (DEUG/Licence/Master I) / University P& M Curie, Paris 6

Positions and Professional Experiences

2014-now

Research engineer, Institut Pasteur.

→½ time: HIV, Inflammation & Persistence Unit (M. Müller-Trutwin). Regulation of inflammation in monkeys resistant or susceptible to AIDS

→½ time: Ebola Task Force (P. Lafayes’ Work Package). Development of a diagnostic point-of-care test for Ebola virus (collaboration with P. Tabeling & L. Magro, ESPCI)

→summer 2015: visiting scientist, CTE of Macenta, Guinea. Diagnostic of Ebola

2007-2014

Research engineer, Regulation of Retroviral Infections Unit (F. Barré-Sinoussi, M. Müller-Trutwins’ team), Institut Pasteur. Immunoregulation of SIV infection in monkeys resistant to AIDS

2004-2007

Research engineer, Platform 2 / DNA microarrays, Institut Pasteur. GPH # 2 “AIDS”, sub-program #1 leaded by M. Müller-Trutwin: Gene expression profiles and signaling pathways differentially regulated in monkeys resistant or susceptible to AIDS

2002-2004

Postdoctoral position as research engineer, CEA (D. Tronik-Leroux laboratory), Genopole of Evry, France: Gene expression profiles during megakaryocytopoiesis in mice

2002

Postdoctoral position, UMR 5533 CNRS (AT. Nurdens’ laboratory), Bordeaux, France: Impact of platelet glycoproteins polymorphisms in cardiovascular diseases

1998-2001

TJ. Kunickis’ laboratory, MEM, The Scripps Research Institute, La Jolla, USA: Study of the factors influencing the integrin alpha-2 gene transcription

1997

UMR 5533 CNRS (AT. Nurdens’ laboratory), Bordeaux, France: Construction of a physical map of Protease-Activated Receptor genes on 5q13

Training

2015

Training to work on Ebola-infected biological samples (PSM III, Diagnostic tests…)/ Institut Pasteur

2008

Basics in Biostatistics / University Paris Diderot, Paris 7

2008

Quality Basics / Institut Pasteur

2007

Animal experimentation level I / Veterinary School of Alfort

Skills

Scientific

Broad range of biomedical laboratory techniques, including nucleic acid handling and related assays, qRT-PCR, library constructions, cloning, microarrays, PFGE, western-blot, ELISA, PBMC isolation, magnetic cell separation, cell culture techniques…

Biosafety level 3 working, SIV/HIV quantifications, handling of human and simian infected samples…

Data analysis (Office, EndNote, GraphPad Prism, Statview, Blast, Clustal-W, Photoshop…)

Project management, grant writing…

Training

2007-2011: Co-supervision of a graduate student (IP)

2004-2007: Supervision of a master student and a graduate student (IP)

Teaching

2012: Course on Animal models for AIDS for the “Université des Jeunes Chercheurs” (Sidaction), Carry-le-Rouet.

2004-2007: Teaching of the practical part of the “Mouse genetics course” on DNA microarrays (IP)

Other activities

2008-2015: In co-charge of the “quality“ supervision for the Unit

2008-2013: Member of the editorial board of the vih.org website

2007-2013: In co-charge of the transcriptomic platform for nonhuman primates and of the french preclinical research database website of the ANRS

2002-2004: Coordinator for the CEA of the Genopole journal “FORUM”

Languages

French (native speaker), English (fluent)

Publications

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