Beatrice Jacquelin joined Michaela Müller-Trutwin’s group at Institut Pasteur as a research engineer in 2004. Throughout the years of her graduate (1998-2001) and postdoctoral (2002-2004) training that she performed at The Scripps Research Institute (USA), at the UMR 5533 CNRS (Bordeaux) and at the Genopole of Evry (CEA), she developed a strong scientific research experience in gene regulation that she applied in the field of hemostasis and hematopoiesis. A good way to get new insights in gene regulations is to study them in pathologic situations. She therefore started to study the mechanisms responsible for aberrant T cell activation leading to AIDS using the SIV-infection models at Institut Pasteur. The focus of her work is now on factors of either susceptibility to SIV-induced inflammation or factors that allow the control of this inflammation. Their identification might deliver the missing key elements for the understanding of how HIV induces AIDS and also novel targets for anti-inflammatory therapies in HIV-infected patients. In parallel, Beatrice is also involved in the Ebola task force program (Pierre Lafaye’s Work Package) to develop an easy-to-use, cheap, fast, accessible and easily disposable test for on-the-field, point-of-care diagnostics.
About
Projects
CV
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Education |
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1998-2001 |
Ph.D. in Biology and Pharmacology of Hemostasis and Vessels / University Paris Diderot (B2T), Paris 7 |
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1997 |
Master II (DEA) in Biology and Pharmacology of Hemostasis and Vessels / University Paris 7 (B2T) |
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1991-1996 |
Degree in Biochemistry (DEUG/Licence/Master I) / University P& M Curie, Paris 6 |
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Positions and Professional Experiences |
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2014-now |
Research engineer, Institut Pasteur. →½ time: HIV, Inflammation & Persistence Unit (M. Müller-Trutwin). Regulation of inflammation in monkeys resistant or susceptible to AIDS →½ time: Ebola Task Force (P. Lafayes’ Work Package). Development of a diagnostic point-of-care test for Ebola virus (collaboration with P. Tabeling & L. Magro, ESPCI) →summer 2015: visiting scientist, CTE of Macenta, Guinea. Diagnostic of Ebola |
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2007-2014 |
Research engineer, Regulation of Retroviral Infections Unit (F. Barré-Sinoussi, M. Müller-Trutwins’ team), Institut Pasteur. Immunoregulation of SIV infection in monkeys resistant to AIDS |
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2004-2007 |
Research engineer, Platform 2 / DNA microarrays, Institut Pasteur. GPH # 2 “AIDS”, sub-program #1 leaded by M. Müller-Trutwin: Gene expression profiles and signaling pathways differentially regulated in monkeys resistant or susceptible to AIDS |
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2002-2004 |
Postdoctoral position as research engineer, CEA (D. Tronik-Leroux laboratory), Genopole of Evry, France: Gene expression profiles during megakaryocytopoiesis in mice |
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2002 |
Postdoctoral position, UMR 5533 CNRS (AT. Nurdens’ laboratory), Bordeaux, France: Impact of platelet glycoproteins polymorphisms in cardiovascular diseases |
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1998-2001 |
TJ. Kunickis’ laboratory, MEM, The Scripps Research Institute, La Jolla, USA: Study of the factors influencing the integrin alpha-2 gene transcription |
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1997 |
UMR 5533 CNRS (AT. Nurdens’ laboratory), Bordeaux, France: Construction of a physical map of Protease-Activated Receptor genes on 5q13 |
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Training |
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2015 |
Training to work on Ebola-infected biological samples (PSM III, Diagnostic tests…)/ Institut Pasteur |
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2008 |
Basics in Biostatistics / University Paris Diderot, Paris 7 |
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2008 |
Quality Basics / Institut Pasteur |
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2007 |
Animal experimentation level I / Veterinary School of Alfort |
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Skills |
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Scientific Broad range of biomedical laboratory techniques, including nucleic acid handling and related assays, qRT-PCR, library constructions, cloning, microarrays, PFGE, western-blot, ELISA, PBMC isolation, magnetic cell separation, cell culture techniques… Biosafety level 3 working, SIV/HIV quantifications, handling of human and simian infected samples… Data analysis (Office, EndNote, GraphPad Prism, Statview, Blast, Clustal-W, Photoshop…) Project management, grant writing… |
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Training 2007-2011: Co-supervision of a graduate student (IP) 2004-2007: Supervision of a master student and a graduate student (IP) |
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Teaching 2012: Course on Animal models for AIDS for the “Université des Jeunes Chercheurs” (Sidaction), Carry-le-Rouet. 2004-2007: Teaching of the practical part of the “Mouse genetics course” on DNA microarrays (IP) |
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Other activities 2008-2015: In co-charge of the “quality“ supervision for the Unit 2008-2013: Member of the editorial board of the vih.org website 2007-2013: In co-charge of the transcriptomic platform for nonhuman primates and of the french preclinical research database website of the ANRS 2002-2004: Coordinator for the CEA of the Genopole journal “FORUM” |
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Languages French (native speaker), English (fluent) |
Publications
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2023SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells., Nat Immunol 2023 Nov; (): .
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2022NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections., Commun Biol 2022 Jul; 5(1): 674.
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2021NK-B cell cross talk induces CXCR5 expression on natural killer cells., iScience 2021 Oct; 24(10): 103109.
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2021Interests of the Non-Human Primate Models for HIV Cure Research., Vaccines (Basel) 2021 Aug; 9(9): .
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2021IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques., Nat Commun 2021 05; 12(1): 2866.
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2021Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections., iScience 2021 Apr; 24(4): 102314.
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2021SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity., Nat Commun 2021 02; 12(1): 1282.
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2021Analysis and annotation of DNA methylation in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips., Epigenomics 2021 02; 13(3): 169-186.
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2021CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., Front Immunol 2021 ; 12(): 695148.
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2020DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections., Clin Epigenetics 2020 Dec; 12(1): 188.
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