Timeline
Ludovic Deriano
Head of Structure
30 Jun 2023
17 May 2023
28 Jun 2022
publication
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Read more07 Mar 2022
11 Jan 2022
news
New publication – The Sec61 translocon is a therapeutic vulnerability in multiple myeloma
Read more05 Jan 2022
publication
The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination
Read more24 Nov 2021
14 Sep 2021
04 May 2021
09 Nov 2020
news
Repair of G1 induced DNA double-strand breaks in S-G2/ breaks in S-G2/M by alternative NHEJ.
Read more05 Nov 2020
project
Study of DNA double-strand break repair regulation in B cells – implication for cancer therapy
Read more16 Oct 2020
05 Dec 2019
04 Jun 2019
publication
Breakage-fusion-bridge events trigger complex genome rearrangements and amplifications in developmentally arrested T cell lymphomas
Read more17 Apr 2019
publication
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function
Read more22 Mar 2019
14 Feb 2019
23 Nov 2018
23 Nov 2018
20 Aug 2018
publication
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Read more27 Jul 2018
publication
Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells
Read more04 Sep 2017
publication
Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination
Read more14 Jun 2017
publication
[Paralogy and redundancy: maintaining genome integrity during V(D)J recombination]
Read more15 Feb 2017
15 Nov 2016
01 Nov 2016
01 Oct 2016
28 Sep 2016
02 Sep 2016
26 Jul 2016
22 Jun 2016
31 Mar 2016
event
Recurrently Breaking Genes in Brain Progenitor Cells may Contribute to Diversity and Disease
Read more02 Feb 2016
publication
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
Read more07 Sep 2015
01 Jul 2015
01 Jul 2015
11 May 2015
23 Oct 2014
20 Apr 2014
publication
RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’
Read more11 Sep 2013
publication
Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage
Read more29 Aug 2013
publication
RAG2’s acidic hinge restricts repair-pathway choice and promotes genomic stability
Read more14 Feb 2013
publication
Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers
Read more01 Jan 2013
publication
The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage
Read more29 Oct 2012
publication
A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing
Read more01 Mar 2011
10 Apr 2009
publication
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
Read more17 Nov 2008
publication
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability
Read more27 Sep 2007
15 Dec 2006
publication
Chronic exposure to sublethal doses of radiation mimetic Zeocin selects for clones deficient in homologous recombination
Read more01 Jun 2006
publication
Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells
Read more01 May 2006
17 Feb 2005
publication
Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway
Read more01 Aug 2003
publication
B-cell chronic lymphocytic leukaemia: a polymorphic family unified by genomic features
Read more12 Sep 2001
publication