Ligne de temps

Ludovic Deriano
Responsable de Structure
28 Jun 2022
publication

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.

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11 Jan 2022
news

New publication – The Sec61 translocon is a therapeutic vulnerability in multiple myeloma

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11 Jan 2022
publication

The Sec61 translocon is a therapeutic vulnerability in multiple myeloma.

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05 Jan 2022
publication

The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination

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24 Nov 2021
publication

Fam72a enforces error-prone DNA repair during antibody diversification

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14 Sep 2021
publication

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.

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04 May 2021
program_project

Initiative Cancer

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09 Nov 2020
news

Repair of G1 induced DNA double-strand breaks in S-G2/ breaks in S-G2/M by alternative NHEJ.

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05 Nov 2020
project

Study of DNA double-strand break repair regulation in B cells – implication for cancer therapy

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16 Oct 2020
publication

Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ.

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05 Dec 2019
event

Journée de la recherche translationnelle 2021 – Cancer and Immunotherapy

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04 Jun 2019
publication

Breakage-fusion-bridge events trigger complex genome rearrangements and amplifications in developmentally arrested T cell lymphomas

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17 Apr 2019
publication

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

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22 Mar 2019
event

Mechanisms and Consequences of Chromosomal Translocations

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14 Feb 2019
team

Physiopathologie du système immunitaire

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23 Nov 2018
publication

The immune system profoundly restricts intratumor genetic heterogeneity

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20 Aug 2018
publication

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

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27 Jul 2018
publication

Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

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04 Sep 2017
publication

Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

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14 Jun 2017
publication

[Paralogy and redundancy: maintaining genome integrity during V(D)J recombination]

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15 Feb 2017
event

Bernardo Reina San Martin seminar

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15 Nov 2016
publication

The RAG Recombinase: Beyond Breaking

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01 Nov 2016
news

PAXX function in V(D)J recombination and Mammalian Development Revealed

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01 Oct 2016
publication

Synthetic lethality between PAXX and XLF in mammalian development

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28 Sep 2016
publication

V(D)J Recombination: Orchestrating Diversity without Damage.

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02 Sep 2016
publication

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

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26 Jul 2016
project

Mechanisms and consequences of chromosomal translocations

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22 Jun 2016
project

Think tank: Cancer

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31 Mar 2016
event

Recurrently Breaking Genes in Brain Progenitor Cells may Contribute to Diversity and Disease

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02 Feb 2016
publication

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

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07 Sep 2015
project

ERC-2012-StG LymphoOncoGenomics

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01 Jul 2015
project

FROM PHYSIOLOGICAL DNA REARRANGEMENTS TO LYMPHOID CANCERS

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01 Jul 2015
project

MECHANISMS OF DNA RECOMBINATION

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11 May 2015
team

Intégrité du Génome, Immunité et Cancer

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23 Oct 2014
publication

Listeria monocytogenes dampens the DNA damage response

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20 Apr 2014
publication

RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’

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11 Sep 2013
publication

Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage

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29 Aug 2013
publication

RAG2’s acidic hinge restricts repair-pathway choice and promotes genomic stability

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14 Feb 2013
publication

Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers

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01 Jan 2013
publication

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage

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29 Oct 2012
publication

A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing

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01 Mar 2011
publication

The RAG2 C terminus suppresses genomic instability and lymphomagenesis

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10 Apr 2009
publication

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates

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17 Nov 2008
publication

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability

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27 Sep 2007
publication

Rag mutations reveal robust alternative end joining

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15 Dec 2006
publication

Chronic exposure to sublethal doses of radiation mimetic Zeocin selects for clones deficient in homologous recombination

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01 Jun 2006
publication

Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells

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01 May 2006
publication

New molecular markers in resistant B-CLL

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17 Feb 2005
publication

Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway

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01 Aug 2003
publication

B-cell chronic lymphocytic leukaemia: a polymorphic family unified by genomic features

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12 Sep 2001
publication

IgE receptor type I-dependent regulation of a Rab3D-associated kinase: a possible link in the calcium-dependent assembly of SNARE complexes

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