Ligne de temps
Ahmed Haouz
Responsable de Structure
05 avr. 2024
publication
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Lire plus13 mars 2024
publication
Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.
Lire plus05 févr. 2024
publication
Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Lire plus07 sept. 2023
publication
Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.
Lire plus21 août 2023
publication
New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex
Lire plus20 juin 2023
publication
Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
Lire plus27 avr. 2023
24 avr. 2023
publication
The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.
Lire plus22 avr. 2023
28 mars 2023
publication
Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.
Lire plus06 mars 2023
publication
The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.
Lire plus02 févr. 2023
publication
Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
Lire plus01 févr. 2023
news
Bacterial pathogenicity: improving understanding of an essential process – molecule secretion
Lire plus11 janv. 2023
publication
Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates
Lire plus01 janv. 2023
publication
Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Lire plus13 déc. 2022
publication
FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.
Lire plus09 août 2022
publication
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Lire plus12 févr. 2022
publication
Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Lire plus07 janv. 2022
publication
Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.
Lire plus01 janv. 2022
publication
Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Lire plus29 déc. 2021
publication
Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.
Lire plus09 déc. 2021
publication
The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.
Lire plus22 nov. 2021
publication
Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Lire plus01 sept. 2021
publication
Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.
Lire plus01 mai 2021
publication
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Lire plus30 avr. 2021
publication
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes
Lire plus13 janv. 2021
publication
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Lire plus13 nov. 2020
publication
Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.
Lire plus06 nov. 2020
publication
Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
Lire plus06 juil. 2020
publication
Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Lire plus01 juin 2020
publication
PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
Lire plus02 avr. 2020
publication
Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.
Lire plus05 févr. 2020
publication
Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.
Lire plus30 janv. 2020
publication
Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.
Lire plus05 déc. 2019
publication
High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur
Lire plus23 avr. 2019
publication
Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor
Lire plus16 mars 2019
publication
The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function
Lire plus20 févr. 2019
publication
Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Lire plus02 févr. 2019
27 déc. 2018
publication
Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy
Lire plus29 oct. 2018
publication
Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography
Lire plus26 sept. 2018
publication
An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins
Lire plus01 sept. 2018
publication
An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins
Lire plus13 août 2018
publication
Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes
Lire plus04 août 2018
publication
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Lire plus15 juil. 2018
17 févr. 2018
publication
Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1
Lire plus01 janv. 2018
publication
Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.
Lire plus25 juil. 2017
publication
OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity
Lire plus23 mai 2017
publication
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.
Lire plus22 févr. 2017
publication
Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.
Lire plus08 juil. 2016
publication
Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase
Lire plus31 mai 2016
publication
Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.
Lire plus18 mai 2016
publication
Structural basis for haem piracy from host haemopexin by Haemophilus influenzae
Lire plus14 nov. 2015
publication
Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa
Lire plus25 août 2015
publication
Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation
Lire plus02 juil. 2015
23 mai 2015
publication
Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans
Lire plus17 févr. 2015
23 janv. 2015
publication
Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A
Lire plus29 nov. 2014
publication
Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones
Lire plus29 oct. 2014
publication
Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition
Lire plus15 oct. 2014
publication
Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase
Lire plus01 oct. 2014
publication
Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Lire plus24 sept. 2014
publication
Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
Lire plus10 sept. 2014
publication
A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase
Lire plus15 août 2014
publication
Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants
Lire plus01 août 2014
publication
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities
Lire plus10 avr. 2014
23 déc. 2013
publication
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Lire plus11 oct. 2013
publication
Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp
Lire plus16 juin 2013
publication
Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad
Lire plus24 sept. 2012
publication
In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?
Lire plus11 sept. 2012
publication
Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis
Lire plus09 juil. 2012
publication
Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway
Lire plus03 mai 2012
publication
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Lire plus26 janv. 2012
publication
Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]
Lire plus12 oct. 2011
publication
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death
Lire plus01 juil. 2011
publication
Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis
Lire plus20 août 2010
publication
Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9
Lire plus13 nov. 2009
publication
Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel
Lire plus23 oct. 2009
publication
DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding
Lire plus04 oct. 2009
23 sept. 2009
publication
Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance
Lire plus04 sept. 2009
publication
Structural plasticity and catalysis regulation of a thermosensor histidine kinase
Lire plus16 janv. 2009
publication
Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis
Lire plus01 janv. 2008
publication
Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1
Lire plus20 déc. 2007
publication
Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima
Lire plus01 oct. 2007
27 juil. 2007
publication
The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria
Lire plus02 juil. 2007
publication
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site
Lire plus15 déc. 2006
publication
The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria
Lire plus22 nov. 2006
publication
Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei
Lire plus02 mai 2006
publication
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Lire plus01 févr. 2003
publication
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism
Lire plus01 juin 2002
publication
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods
Lire plus01 juin 2002