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Responsable de Plateforme
Martine Cohen-Solal (PI)
New TARGETs for osteoporosis: from mesenchymal stem cells to the regulation of osteogenesis and BONE mass.
Marco Bellinzoni (PI)
Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]
Crl: a “binding and deliver” SigmaS chaperone
Françoise Norel-Bozouklian (PI)
Regulation of many key biological processes in bacteria involves the interplay between Sigma factors and anti-Sigma factors that typically attenuate Sigma factor function by restricting its access to RNA polymerase (RNAP). In contrast, our […]
CyaA secretion, folding and translocation across membrane
Alexandre Chenal (PI)
CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]
Hélène Munier-Lehmann (PI)
Inosine-5′-monophosphate dehydrogenase (IMPDH) is ubiquitously essential for the biosynthesis of guanosine nucleotides and catalyzes the NAD-dependent oxidation of IMP to XMP. IMPDH is a major target in the design of both antitumor and immunosuppresive […]
Paola Minoprio (PI)
Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]
X-Ray Diffraction service : – A RIGAKU micromax 007 X-ray generator with standard rotating anode (wavelength 1.54 Å). – A system of multi-layer X-ray optics from OSMIC. – A mar345dtb image plate X-ray […]
The MATRIXMAKER service To refine the conditions of crystallization, the robot Matrixmaker allows to obtain solutions of crystallization on various kind of supports (tubes 50 ml, tubes 15 ml, tube Eppendorf 1.5 or 2 […]
Application process of crystallization at 18°C or 4°C Procedure : Bring the proteins to the Platform with the filled FORM. In the platform we can setup high-throughput crystallization experiments (18°C or 4°C) with […]
Serveur Bi-Processeur Intel Xeon baie de disques RAID Fibrenetix For datas analysis and storages
X Ray generator Anode tournante (Rigaku MicroMax-O7) avec deux détecteurs à plaque image (MAR-345, MAR-300) Cryogenic systems (Cryojet Oxford Instruments, Oxford Cryosystem) for tridimensional structures of proteins
Robot Matrixmaker Refinement of cristallization solutions Possible supports: Deep-Well, VDX(24 puits), tubes Eppendorf, 15ml, 50ml.
Robot Mosquito Nanodrop cristallization Drop volumes from 100 to 1000nl Sitting drop Hanging drop possible
Robot Cartesian technologies Cartesian technologies Nanodrop criistallization One drop volume : 200nl Sitiing drop only
2018Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes, PLoS Biol. 2018 Aug;16(8):e2006357.
2018Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance, J. Struct. Biol. 2018 Aug;.
2018Structural plasticity of the HHD2 domain of whirlin, FEBS J. 2018 Jul;.
2018Structural insights into the signalling mechanisms of two-component systems, Nat. Rev. Microbiol. 2018 Jul;.
2018A step-by-step guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase, J. Biol. Chem. 2018 Apr;293(16):6000-6010.
2018Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1, FEBS Lett. 2018 Feb;.
2017Structure and function of the Leptospira interrogans peroxide stress regulator (PerR), an atypical PerR devoid of a structural metal-binding site, J. Biol. Chem. 2017 Nov;.
2017Structure-function dissection of the Pseudorabies virus glycoprotein B fusion loops, J. Virol. 2017 Oct;.
2017Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study, PLoS ONE 2017;12(8):e0183198.
2017OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity, J. Mol. Biol. 2017 Sep;429(18):2816-2824.
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