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Responsable de Plateforme
Marco Bellinzoni (PI)
Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]
Crl: a “binding and deliver” SigmaS chaperone
Françoise Norel-Bozouklian (PI)
Regulation of many key biological processes in bacteria involves the interplay between Sigma factors and anti-Sigma factors that typically attenuate Sigma factor function by restricting its access to RNA polymerase (RNAP). In contrast, our […]
CyaA secretion, folding and translocation across membrane
Alexandre Chenal (PI)
CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]
Hélène Munier-Lehmann (PI)
Inosine-5′-monophosphate dehydrogenase (IMPDH) is ubiquitously essential for the biosynthesis of guanosine nucleotides and catalyzes the NAD-dependent oxidation of IMP to XMP. IMPDH is a major target in the design of both antitumor and immunosuppresive […]
Paola Minoprio (PI)
Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]
X-Ray Diffraction service : – A RIGAKU micromax 007 X-ray generator with standard rotating anode (wavelength 1.54 Å). – A system of multi-layer X-ray optics from OSMIC. – A mar345dtb image plate X-ray […]
The MATRIXMAKER service To refine the conditions of crystallization, the robot Matrixmaker allows to obtain solutions of crystallization on various kind of supports (tubes 50 ml, tubes 15 ml, tube Eppendorf 1.5 or 2 […]
Application process of crystallization Procedure ? Bring the proteins to the Platform with the form to complete. The screening is made on the Synquad robot Cartesian (sitting drop method only) or on the […]
AKTA Purifier For the purification of proteins
Serveur Bi-Processeur Intel Xeon baie de disques RAID Fibrenetix For datas analysis and storages
X Ray generator Anode tournante (Rigaku MicroMax-O7) avec deux détecteurs à plaque image (MAR-345, MAR-300) Cryogenic systems (Cryojet Oxford Instruments, Oxford Cryosystem) for tridimensional structures of proteins
Robot Matrixmaker Refinement of cristallization solutions Possible supports: Deep-Well, VDX(24 puits), tubes Eppendorf, 15ml, 50ml.
Robot FormulatrixImaging of drops and crystals Imaging scheduling
Robot Mosquito Nanodrop cristallization Drop volumes from 100 to 1000nl Sitting drop Hanging drop possible
Robot Cartesian technologies Cartesian technologies Nanodrop criistallization One drop volume : 200nl Sitiing drop only
Robot Genesis workstation 150 Tecan Pipeeting station
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