Timeline

Ahmed Haouz

Head of Structure

01 Dec 2024

publication

Conformational variability in the D2 loop of Plasmodium Apical Membrane antigen 1.

27 Sep 2024

publication

Bifunctional Hexadentate Pyclen-based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-18F Ternary Complex.

11 Sep 2024

publication

Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.

19 Jul 2024

publication

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.

21 Jun 2024

publication

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.

05 May 2024

publication

Vestibular Modulation by Stimulant Derivatives in a Pentameric Ligand-Gated Ion Channel

05 Apr 2024

publication

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

13 Mar 2024

publication

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

05 Feb 2024

publication

Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.

07 Sep 2023

publication

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

21 Aug 2023

publication

New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex

20 Jun 2023

publication

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

27 Apr 2023

project

DNA-binding mechanism and evolution of replication protein A

24 Apr 2023

publication

The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.

22 Apr 2023

publication

DNA-binding mechanism and evolution of replication protein A.

28 Mar 2023

publication

Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.

06 Mar 2023

publication

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.

02 Feb 2023

publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

01 Feb 2023

news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

11 Jan 2023

publication

Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates

01 Jan 2023

publication

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

13 Dec 2022

publication

FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.

09 Aug 2022

publication

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

12 Feb 2022

publication

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

07 Jan 2022

publication

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.

01 Jan 2022

publication

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

29 Dec 2021

publication

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.

09 Dec 2021

publication

The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.

22 Nov 2021

publication

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.

01 Sep 2021

publication

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

01 May 2021

publication

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

30 Apr 2021

publication

A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes

13 Jan 2021

publication

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

13 Nov 2020

publication

Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.

06 Nov 2020

publication

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

06 Jul 2020

publication

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

01 Jun 2020

publication

PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.

02 Apr 2020

publication

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.

05 Feb 2020

publication

Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.

30 Jan 2020

publication

Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.

05 Dec 2019

publication

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

23 Apr 2019

publication

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor

16 Mar 2019

publication

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function

20 Feb 2019

publication

Orthobunyavirus spike architecture and recognition by neutralizing antibodies.

02 Feb 2019

publication

First-in-class allosteric inhibitors of bacterial IMPDHs

27 Dec 2018

publication

Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy

29 Oct 2018

publication

Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

26 Sep 2018

publication

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins

01 Sep 2018

publication

An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins

13 Aug 2018

publication

Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes

04 Aug 2018

publication

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

15 Jul 2018

publication

Structural insights into the signalling mechanisms of two-component systems

17 Feb 2018

publication

Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1

01 Jan 2018

publication

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

25 Jul 2017

publication

OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity

23 May 2017

publication

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.

22 Feb 2017

publication

Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.

08 Jul 2016

publication

Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase

31 May 2016

publication

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

18 May 2016

publication

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae

14 Nov 2015

publication

Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa

25 Aug 2015

publication

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

02 Jul 2015

project

Chagas

23 May 2015

publication

Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans

17 Feb 2015

team

Crystallography

23 Jan 2015

publication

Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A

29 Nov 2014

publication

Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

29 Oct 2014

publication

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

15 Oct 2014

publication

Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase

01 Oct 2014

publication

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

24 Sep 2014

publication

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

10 Sep 2014

publication

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

15 Aug 2014

publication

Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

01 Aug 2014

publication

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities

10 Apr 2014

publication

Structural basis of eukaryotic cell-cell fusion

23 Dec 2013

publication

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

01 Dec 2013

publication

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp.

16 Jun 2013

publication

Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad

24 Sep 2012

publication

In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?

11 Sep 2012

publication

Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis

09 Jul 2012

publication

Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway

03 May 2012

publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

26 Jan 2012

publication

Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]

12 Oct 2011

publication

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death

01 Jul 2011

publication

Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis

20 Aug 2010

publication

Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9

13 Nov 2009

publication

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

23 Oct 2009

publication

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

04 Oct 2009

publication

Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon

23 Sep 2009

publication

Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance

04 Sep 2009

publication

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

16 Jan 2009

publication

Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

01 Jan 2008

publication

Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1

20 Dec 2007

publication

Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima

01 Oct 2007

publication

The crystal structure of Trypanosoma cruzi arginine kinase

27 Jul 2007

publication

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

02 Jul 2007

publication

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site

15 Dec 2006

publication

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria

22 Nov 2006

publication

Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei

02 May 2006

publication

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

01 Feb 2003

publication

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

01 Jun 2002

publication

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

01 Jun 2002

publication

A little guide for advanced search:

Conformational variability in the D2 loop of Plasmodium Apical Membrane antigen 1.

Bifunctional Hexadentate Pyclen-based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-18F Ternary Complex.

Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.

Vestibular Modulation by Stimulant Derivatives in a Pentameric Ligand-Gated Ion Channel

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

DNA-binding mechanism and evolution of replication protein A

The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.

DNA-binding mechanism and evolution of replication protein A.

Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.

The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.

Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.

Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function

Orthobunyavirus spike architecture and recognition by neutralizing antibodies.

First-in-class allosteric inhibitors of bacterial IMPDHs

Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy

Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins

An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins

Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

Structural insights into the signalling mechanisms of two-component systems

Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.

Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.

Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae

Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

Chagas

Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans

Crystallography

Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A

Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities

Structural basis of eukaryotic cell-cell fusion

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp.

Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad

In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?