Timeline

Ahmed Haouz
Head of Structure
11 Sep 2024
publication

Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.

Read more
19 Jul 2024
publication

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.

Read more
21 Jun 2024
publication

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.

Read more
05 Apr 2024
publication

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

Read more
13 Mar 2024
publication

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

Read more
05 Feb 2024
publication

Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.

Read more
07 Sep 2023
publication

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

Read more
21 Aug 2023
publication

New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex

Read more
20 Jun 2023
publication

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.

Read more
27 Apr 2023
project

DNA-binding mechanism and evolution of replication protein A

Read more
24 Apr 2023
publication

The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.

Read more
22 Apr 2023
publication

DNA-binding mechanism and evolution of replication protein A.

Read more
28 Mar 2023
publication

Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.

Read more
06 Mar 2023
publication

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.

Read more
02 Feb 2023
publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Read more
01 Feb 2023
news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

Read more
11 Jan 2023
publication

Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates

Read more
01 Jan 2023
publication

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.

Read more
13 Dec 2022
publication

FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.

Read more
09 Aug 2022
publication

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

Read more
12 Feb 2022
publication

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

Read more
07 Jan 2022
publication

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.

Read more
01 Jan 2022
publication

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.

Read more
29 Dec 2021
publication

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.

Read more
09 Dec 2021
publication

The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.

Read more
22 Nov 2021
publication

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.

Read more
01 Sep 2021
publication

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

Read more
01 May 2021
publication

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

Read more
30 Apr 2021
publication

A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes

Read more
13 Jan 2021
publication

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.

Read more
13 Nov 2020
publication

Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.

Read more
06 Nov 2020
publication

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.

Read more
06 Jul 2020
publication

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

Read more
01 Jun 2020
publication

PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.

Read more
02 Apr 2020
publication

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.

Read more
05 Feb 2020
publication

Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.

Read more
30 Jan 2020
publication

Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.

Read more
05 Dec 2019
publication

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

Read more
23 Apr 2019
publication

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor

Read more
16 Mar 2019
publication

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function

Read more
20 Feb 2019
publication

Orthobunyavirus spike architecture and recognition by neutralizing antibodies.

Read more
02 Feb 2019
publication

First-in-class allosteric inhibitors of bacterial IMPDHs

Read more
27 Dec 2018
publication

Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy

Read more
29 Oct 2018
publication

Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

Read more
26 Sep 2018
publication

An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins

Read more
01 Sep 2018
publication

An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins

Read more
13 Aug 2018
publication

Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes

Read more
04 Aug 2018
publication

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

Read more
15 Jul 2018
publication

Structural insights into the signalling mechanisms of two-component systems

Read more
17 Feb 2018
publication

Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1

Read more
01 Jan 2018
publication

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

Read more
25 Jul 2017
publication

OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity

Read more
23 May 2017
publication

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.

Read more
22 Feb 2017
publication

Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases.

Read more
08 Jul 2016
publication

Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase

Read more
31 May 2016
publication

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

Read more
18 May 2016
publication

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae

Read more
14 Nov 2015
publication

Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa

Read more
25 Aug 2015
publication

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

Read more
02 Jul 2015
project

Chagas

Read more
23 May 2015
publication

Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans

Read more
17 Feb 2015
team

Crystallography

Read more
23 Jan 2015
publication

Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A

Read more
29 Nov 2014
publication

Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

Read more
29 Oct 2014
publication

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

Read more
15 Oct 2014
publication

Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase

Read more
01 Oct 2014
publication

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

Read more
24 Sep 2014
publication

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

Read more
10 Sep 2014
publication

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

Read more
15 Aug 2014
publication

Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

Read more
01 Aug 2014
publication

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities

Read more
10 Apr 2014
publication

Structural basis of eukaryotic cell-cell fusion

Read more
23 Dec 2013
publication

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Read more
11 Oct 2013
publication

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp

Read more
16 Jun 2013
publication

Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad

Read more
24 Sep 2012
publication

In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?

Read more
11 Sep 2012
publication

Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis

Read more
09 Jul 2012
publication

Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway

Read more
03 May 2012
publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Read more
26 Jan 2012
publication

Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]

Read more
12 Oct 2011
publication

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death

Read more
01 Jul 2011
publication

Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis

Read more
20 Aug 2010
publication

Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9

Read more
13 Nov 2009
publication

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

Read more
23 Oct 2009
publication

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

Read more
04 Oct 2009
publication

Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon

Read more
23 Sep 2009
publication

Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance

Read more
04 Sep 2009
publication

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

Read more
16 Jan 2009
publication

Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

Read more
01 Jan 2008
publication

Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1

Read more
20 Dec 2007
publication

Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima

Read more
01 Oct 2007
publication

The crystal structure of Trypanosoma cruzi arginine kinase

Read more
27 Jul 2007
publication

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

Read more
02 Jul 2007
publication

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site

Read more
15 Dec 2006
publication

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria

Read more
22 Nov 2006
publication

Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei

Read more
02 May 2006
publication

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

Read more
01 Feb 2003
publication

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

Read more
01 Jun 2002
publication

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

Read more
01 Jun 2002
publication

The crystal structure of the mouse apoptosis-inducing factor AIF

Read more