Timeline
Ahmed Haouz
Head of Structure
11 Sep 2024
publication
Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.
Read more19 Jul 2024
publication
Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.
Read more21 Jun 2024
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Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.
Read more05 Apr 2024
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Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Read more13 Mar 2024
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Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.
Read more05 Feb 2024
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Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Read more07 Sep 2023
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Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.
Read more21 Aug 2023
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New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex
Read more20 Jun 2023
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
Read more27 Apr 2023
24 Apr 2023
publication
The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.
Read more22 Apr 2023
28 Mar 2023
publication
Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.
Read more06 Mar 2023
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The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.
Read more02 Feb 2023
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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
Read more01 Feb 2023
news
Bacterial pathogenicity: improving understanding of an essential process – molecule secretion
Read more11 Jan 2023
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Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates
Read more01 Jan 2023
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Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Read more13 Dec 2022
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FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.
Read more09 Aug 2022
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Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Read more12 Feb 2022
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Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Read more07 Jan 2022
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Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.
Read more01 Jan 2022
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Read more29 Dec 2021
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Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.
Read more09 Dec 2021
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The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.
Read more22 Nov 2021
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Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Read more01 Sep 2021
publication
Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.
Read more01 May 2021
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A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Read more30 Apr 2021
publication
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes
Read more13 Jan 2021
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Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Read more13 Nov 2020
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Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.
Read more06 Nov 2020
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Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
Read more06 Jul 2020
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Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Read more01 Jun 2020
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PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
Read more02 Apr 2020
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Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.
Read more05 Feb 2020
publication
Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.
Read more30 Jan 2020
publication
Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.
Read more05 Dec 2019
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High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur
Read more23 Apr 2019
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Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor
Read more16 Mar 2019
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The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function
Read more20 Feb 2019
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Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Read more02 Feb 2019
27 Dec 2018
publication
Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy
Read more29 Oct 2018
publication
Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography
Read more26 Sep 2018
publication
An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins
Read more01 Sep 2018
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An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins
Read more13 Aug 2018
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Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes
Read more04 Aug 2018
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Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Read more15 Jul 2018
17 Feb 2018
publication
Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1
Read more01 Jan 2018
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Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.
Read more25 Jul 2017
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OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity
Read more23 May 2017
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Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.
Read more22 Feb 2017
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Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.
Read more08 Jul 2016
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Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase
Read more31 May 2016
publication
Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.
Read more18 May 2016
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Structural basis for haem piracy from host haemopexin by Haemophilus influenzae
Read more14 Nov 2015
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Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa
Read more25 Aug 2015
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Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation
Read more02 Jul 2015
23 May 2015
publication
Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans
Read more17 Feb 2015
23 Jan 2015
publication
Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A
Read more29 Nov 2014
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Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones
Read more29 Oct 2014
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Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition
Read more15 Oct 2014
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Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase
Read more01 Oct 2014
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Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Read more24 Sep 2014
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Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
Read more10 Sep 2014
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A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase
Read more15 Aug 2014
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Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants
Read more01 Aug 2014
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6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities
Read more10 Apr 2014
23 Dec 2013
publication
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Read more11 Oct 2013
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Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp
Read more16 Jun 2013
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Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad
Read more24 Sep 2012
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In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?
Read more11 Sep 2012
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Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis
Read more09 Jul 2012
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Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway
Read more03 May 2012
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Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Read more26 Jan 2012
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Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]
Read more12 Oct 2011
publication
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death
Read more01 Jul 2011
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Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis
Read more20 Aug 2010
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Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9
Read more13 Nov 2009
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Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel
Read more23 Oct 2009
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DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding
Read more04 Oct 2009
23 Sep 2009
publication
Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance
Read more04 Sep 2009
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Structural plasticity and catalysis regulation of a thermosensor histidine kinase
Read more16 Jan 2009
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Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis
Read more01 Jan 2008
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Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1
Read more20 Dec 2007
publication
Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima
Read more01 Oct 2007
27 Jul 2007
publication
The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria
Read more02 Jul 2007
publication
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site
Read more15 Dec 2006
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The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria
Read more22 Nov 2006
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Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei
Read more02 May 2006
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The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Read more01 Feb 2003
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Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism
Read more01 Jun 2002
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Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods
Read more01 Jun 2002