Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Role of Neuroinflammation in Adult Neurogenesis
Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases. Also, it has been demonstrated to affect important processes in the brain, such […]
The link between olfaction and emotion in bipolar disorders
Bipolar disorders (BD) is a prevalent and debilitating chornic psychiatric illness that generates a considerable cost for the society. Beyond mood episodes, manic or depressive, growing evidence has shown that BD patients even during […]
Functional consequences of congenital cytomegalovirus infection on the central nervous system
Human cytomegalovirus (CMV) is the first cause of congenital malformation resulting from viral infection, and the leading cause of mental retardation and hearing loss. We are assessing the impact of congenital CMV infection on […]
Affective dimension of sensory representation
The sense of smell has to deal with numerous odors which can trigger various affective responses. We like or dislike a given odorant even before recognizing the nature of the smell. As a result […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Bacteria produce hundreds of volatile compounds, important for the crafting of microbe-based foods like wine, beer, or cheese. Although the odorant chemicals emitted by bacteria were rarely characterized in the context of bacteria-bacteria or bacteria-host […]
Vieillissement et longévité
D’après l’OMS, entre 2000 et 2050, la proportion de la population mondiale de plus de 60 ans doublera pour passer d’environ 11% à 22%. Actuellement la plupart des personnes âgées décèdent de maladies non […]
INCEPTION – INstitut Convergences pour l’étude de l’Émergence des Pathologies au Travers des Individus et des populatiONs et des
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Grand Programme Fédérateur Microbes & Brain
Concept général du programme Le Grand Programme fédérateur Microbes & Brain (GPF M&B) réunit 17 équipes internationales de renom (Institut Pasteur Paris, Instituts Pasteur du réseau, Inserm, APHP) dans les domaines des Neurosciences, de […]
OLFACTORY MEANS USEFUL IN THE DIAGNOSIS AND TREATMENT OF MOOD DEPRESSION
The application relates to the measure of olfactory discrimination capacity in subjects affected by a psychiatric disorder or disease involving mood disturbance, more particularly mood depression. The application provides means that are especially adapted […]
2017Sensory deprivation increases phagocytosis of adult-born neurons by activated microglia in the olfactory bulb., Brain Behav Immun. 2017 Feb;60:38-43. .
2017Loss-of-function of PTPR γ and ζ, observed in sporadic schizophrenia, causes brain region-specific deregulation of monoamine levels and altered behavior in mice, Psychopharmacology (Berl). 2017 Feb;234(4):575-587. .
2016GABAB Receptors Tune Cortical Feedback to the Olfactory Bulb, J. Neurosci. 2016 Aug;36(32):8289-304.
2016Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb., Neuron. 2016 Jul 20;91(2):384-96.
2016Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice, J. Neurosci. 2016 Jan;36(2):518-31.
2015Adult neurogenesis and the future of the rejuvenating brain circuits, Neuron 2015 Apr;86(2):387-401.
2015Commentary: “Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories”, Front Neurosci 2015;9:110.
2014Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb, J. Neurosci. 2014 Oct;34(43):14430-42.
2014Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons, Proc. Natl. Acad. Sci. U.S.A. 2014 Sep;111(38):13984-9.
2014The endocannabinoid system controls food intake via olfactory processes, Nat. Neurosci. 2014 Mar;17(3):407-15.
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