Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. nAChRs alpha5 subunit locates in key regions for addiction in the brain, with a genetic variant associated with a lower prevalence of CocAdd in three independent case-control studies. Since our collaboration started in 2014, we have gathered further supporting evidence for the links between nAChR alpha5 subunit and CocAdd (Human genetics, self-administration in transgenic rats, in vitro nAChRs concatemers). We now want to further characterize this subunit’s function in CocAdd using complementary, cutting-edge expertise to investigate all its genetic variants by NGS in Human CocAdd, testing the most impactful variants in rodent and molecular models. This will provide a benchmark for biomarkers and pharmacological development in CocAdd.
- Project Coordinator is Professor Frank Bellivier (AP-HP/INSERM UMR-S1144)
- Group leader for clinical data is Dr Florence Vorspan (AP-HP/INSERM UMR-S1144)
- DNA sequencing will be performed by the Evry Génopole (Anne Boland) supervised by ‘France Génomique’ (Jean-François Deleuze)