Having begun my research career investigating mitochondria in plants and then neurological diseases, I discovered the first mutations of the NLGN3, NLGN4X and SHANK3 genes in autism highlighting the main role of the synapse in this complex condition. Currently, my laboratory gathers psychiatrists, neuroscientists and geneticists to understand the interplay between common and rare variants in autism. I lead the genetic work package for InovAND in France and AIMS-2-TRIALS and CANDY in Europe. These large projects are dedicated to translational research on autism. Both projects are focused on deep-phenotyping of individuals with autism and controls including brain imaging (EEG and MRI) and a battery of cognitive tests. My group is currently developing new methods for analysing whole genome and brain imaging data as well as new paradigms for characterizing mouse social and vocal behaviours. I am also the PI of INCEPTION, a large project at Institut Pasteur that applies integrative biology to understand the emergence of diseases in populations and individuals. I am a member of the European Molecular Biology Organisation (EMBO), the French Academy of Sciences, the Academia Europaea and the National Ethical Committe (CCNE). My aim is to provide knowledge-based discoveries for a better diagnostic, care, and integration of individuals with autism and neurodevelopmental disorders.
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Trouvez de précieux conseils du service de pédopsychiatrie du Pr Richard Delorme (Hôpital Robert-Debré) sur CléPsy.
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2023Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice., Front Mol Neurosci 2023 ; 16(): 1139118.
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2022Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions., Brain 2022 Sep; (): .
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2022Insights from an autism imaging biomarker challenge: Promises and threats to biomarker discovery., Neuroimage 2022 Jul; 255(): 119171.
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2021Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands., Autism Res 2021 Jul; (): .
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2021Operative list of genes associated with autism and neurodevelopmental disorders based on database review., Mol Cell Neurosci 2021 Jun; 113(): 103623.
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2020Mass-spectrometry analysis of the human pineal proteome during night and day and in autism., J Pineal Res 2020 Dec; (): e12713.
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2020Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia., Nat Commun 2020 Oct; 11(1): 5272.
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2020Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia., Mol Psychiatry 2020 Oct; (): .
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2020HyPyP: a Hyperscanning Python Pipeline for inter-brain connectivity analysis., Soc Cogn Affect Neurosci 2020 Oct; (): .
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2020Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome., Am J Psychiatry 2020 Sep; (): appiajp202019080834.
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