Timeline

Frédéric Tangy

Permanent Researcher

09 Mar 2024

publication

Comparative analysis of rabies pathogenic and vaccine strains detection by RIG-I-like receptors.

05 Feb 2024

team

Institut Pasteur-Oncovita joint laboratory

01 Jan 2024

publication

Applying Reverse Genetics to Study Measles Virus Interactions with the Host.

19 Dec 2023

publication

NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway.

30 Sep 2023

publication

Novel Antiviral Molecules against Ebola Virus Infection.

11 Mar 2023

publication

Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys.

15 Jul 2022

publication

Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1.

22 Dec 2021

publication

sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs

14 Dec 2021

project

Towards understanding of immunostimulatory properties of SARS-CoV-2 RNAs

01 Dec 2021

publication

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters.

09 Sep 2021

course

MOOC Viruses and Human Cancers

01 Sep 2021

publication

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

09 Jun 2021

publication

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains.

27 Jan 2021

publication

Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65-iASPP Protein Complex.

27 Oct 2020

publication

Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

15 Jan 2019

publication

Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen.

01 Nov 2018

publication

hCD46 receptor is not required for measles vaccine Schwarz strain replication in vivo: Type-I IFN is the species barrier in mice.

01 Oct 2018

publication

DI-tector: defective interfering viral genomes’ detector for next-generation sequencing data.

10 Jul 2018

publication

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes.

25 Sep 2017

event

10-Year Anniversary of the Institut Pasteur International Vaccinology Course

21 Sep 2017

event

2017 INTERNATIONAL SOCIETY FOR VACCINES ANNUAL CONGRESS at INSTITUT PASTEUR

14 Aug 2017

publication

Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response

24 Apr 2017

event

GPF Vaccinology day

27 Feb 2017

event

VIROLOGY DEPARTMENT SEMINAR

18 Oct 2016

publication

Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells.

12 Feb 2016

project

Group for AIDS Research

08 Oct 2015

project

GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.

08 Oct 2015

project

GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates

07 Oct 2015

program_project

Major Federating Program Vaccinology

01 Oct 2015

patent

A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection (E14305984.8)

26 Sep 2015

project

Comics on vaccination

28 Jul 2015

project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

04 Jul 2015

project

Bivalent vaccines derived from measles vaccine

30 Jun 2015

publication

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

02 Mar 2015

publication

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial.

06 Jan 2015

publication

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

01 Jan 2015

publication

A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions

23 Dec 2014

publication

Evidence for an intranasal immune response to human respiratory syncytial virus infection in cynomolgus macaques

29 Aug 2014

publication

Use of SLAM and PVRL4 and identification of pro-HB-EGF as cell entry receptors for wild type phocine distemper virus

05 May 2014

publication

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

28 Jan 2014

publication

Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein

27 Jan 2014

publication

Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens.

17 Oct 2013

publication

Yellow fever vaccine attenuation revealed: loss of diversity

03 Oct 2013

publication

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

30 Sep 2013

publication

Vaccines in development against West Nile virus

07 Aug 2013

publication

The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication

04 Jun 2013

publication

A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus.

01 Jun 2013

publication

Species-specific impact of the autophagy machinery on Chikungunya virus infection.

01 Apr 2013

publication

Identification of RNA partners of viral proteins in infected cells.

28 Mar 2013

publication

Antitumor Virotherapy by Attenuated Measles Virus (MV)

20 Mar 2013

publication

On dihydroorotate dehydrogenases and their inhibitors and uses

14 Jan 2013

publication

The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells

13 Dec 2012

publication

RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection

14 Sep 2012

publication

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2

13 Sep 2012

publication

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

08 Aug 2012

publication

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase

02 May 2012

publication

Measles vaccine expressing the secreted form of West Nile virus envelope glycoprotein induces protective immunity in squirrel monkeys, a new model of West Nile virus infection

02 May 2012

publication

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes

01 Mar 2012

publication

Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.

03 Sep 2011

publication

A chimeric measles virus with a lentiviral envelope replicates exclusively in CD4+/CCR5+ cells

20 Jul 2011

publication

The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication

09 Sep 2010

publication

Virus-host protein interactions in RNA viruses

03 Aug 2010

publication

Pediatric measles vaccine expressing a dengue tetravalent antigen elicits neutralizing antibodies against all four dengue viruses

14 Apr 2010

publication

Enhanced gene silencing in cells cured of persistent virus infection by RNA interference

11 Nov 2009

publication

Structure of the nucleoprotein binding domain of Mokola virus phosphoprotein

27 Oct 2009

publication

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

18 Sep 2009

publication

Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor

17 Jul 2009

publication

NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein

22 Jun 2009

publication

Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS

05 Apr 2009

publication

Live attenuated measles vaccine expressing HIV-1 Gag virus like particles covered with gp160DeltaV1V2 is strongly immunogenic

12 Nov 2008

publication

Inhibition of IFN-alpha/beta signaling by two discrete peptides within measles virus V protein that specifically bind STAT1 and STAT2

17 Jun 2008

publication

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

30 May 2008

publication

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

12 Dec 2007

publication

Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virus

14 Sep 2007

publication

Recombinant vector derived from live attenuated measles virus: potential for flavivirus vaccines

07 Aug 2007

publication

Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signaling

22 Aug 2005

publication

A recombinant live attenuated measles vaccine vector primes effective HLA-A0201-restricted cytotoxic T lymphocytes and broadly neutralizing antibodies against HIV-1 conserved epitopes

01 May 2005

publication

A paediatric vaccination vector based on live attenuated measles vaccine

10 Apr 2005

publication

The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro

01 Jan 2005

publication

Live attenuated measles vaccine as a potential multivalent pediatric vaccination vector

15 Dec 2004

publication

A chimeric human T cell leukemia virus type I bearing a deltaR Moloney-murine leukemia virus envelope infects mice persistently and induces humoral and cellular immune responses.

10 Dec 2004

publication

Live measles vaccine expressing the secreted form of the West Nile virus envelope glycoprotein protects against West Nile virus encephalitis

01 Jan 2004

publication

A single injection of recombinant measles virus vaccines expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses to HIV

01 Aug 2002

publication

A little guide for advanced search:

Comparative analysis of rabies pathogenic and vaccine strains detection by RIG-I-like receptors.

Institut Pasteur-Oncovita joint laboratory

Applying Reverse Genetics to Study Measles Virus Interactions with the Host.

NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway.

Novel Antiviral Molecules against Ebola Virus Infection.

Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys.

Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1.

sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs

Towards understanding of immunostimulatory properties of SARS-CoV-2 RNAs

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters.

MOOC Viruses and Human Cancers

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains.

Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65-iASPP Protein Complex.

Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen.

hCD46 receptor is not required for measles vaccine Schwarz strain replication in vivo: Type-I IFN is the species barrier in mice.

DI-tector: defective interfering viral genomes’ detector for next-generation sequencing data.

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes.

10-Year Anniversary of the Institut Pasteur International Vaccinology Course

2017 INTERNATIONAL SOCIETY FOR VACCINES ANNUAL CONGRESS at INSTITUT PASTEUR

Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response

GPF Vaccinology day

VIROLOGY DEPARTMENT SEMINAR

Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells.

Group for AIDS Research

GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.

GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates

Major Federating Program Vaccinology

A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection (E14305984.8)

Comics on vaccination

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

Bivalent vaccines derived from measles vaccine

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial.

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions

Evidence for an intranasal immune response to human respiratory syncytial virus infection in cynomolgus macaques

Use of SLAM and PVRL4 and identification of pro-HB-EGF as cell entry receptors for wild type phocine distemper virus

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein

Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens.

Yellow fever vaccine attenuation revealed: loss of diversity

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

Vaccines in development against West Nile virus

The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication

A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus.

Species-specific impact of the autophagy machinery on Chikungunya virus infection.

Identification of RNA partners of viral proteins in infected cells.

Antitumor Virotherapy by Attenuated Measles Virus (MV)

On dihydroorotate dehydrogenases and their inhibitors and uses

The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells

RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase

Measles vaccine expressing the secreted form of West Nile virus envelope glycoprotein induces protective immunity in squirrel monkeys, a new model of West Nile virus infection

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes

Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.

A chimeric measles virus with a lentiviral envelope replicates exclusively in CD4+/CCR5+ cells

The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication

Virus-host protein interactions in RNA viruses

Pediatric measles vaccine expressing a dengue tetravalent antigen elicits neutralizing antibodies against all four dengue viruses

Enhanced gene silencing in cells cured of persistent virus infection by RNA interference

Structure of the nucleoprotein binding domain of Mokola virus phosphoprotein

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor

NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein

Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS

Live attenuated measles vaccine expressing HIV-1 Gag virus like particles covered with gp160DeltaV1V2 is strongly immunogenic

Inhibition of IFN-alpha/beta signaling by two discrete peptides within measles virus V protein that specifically bind STAT1 and STAT2

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virus

Recombinant vector derived from live attenuated measles virus: potential for flavivirus vaccines

Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signaling

A recombinant live attenuated measles vaccine vector primes effective HLA-A0201-restricted cytotoxic T lymphocytes and broadly neutralizing antibodies against HIV-1 conserved epitopes

A paediatric vaccination vector based on live attenuated measles vaccine

The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro