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© Research
Publication : Virology

Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virology - 28 Jan 2014

Escriou N, Callendret B, Lorin V, Combredet C, Marianneau P, Février M, Tangy F

Link to Pubmed [PMID] – 24606680

Virology 2014 Mar;452-453:32-41

The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the respiratory tract, a vaccine inducing mucosal long-term protection would be an asset to control new epidemics. To this aim, we generated live attenuated recombinant measles vaccine (MV) candidates expressing either the membrane-anchored SARS-CoV spike (S) protein or its secreted soluble ectodomain (Ssol). In mice susceptible to measles virus, recombinant MV expressing the anchored full-length S induced the highest titers of neutralizing antibodies and fully protected immunized animals from intranasal infectious challenge with SARS-CoV. As compared to immunization with adjuvanted recombinant Ssol protein, recombinant MV induced stronger and Th1-biased responses, a hallmark of live attenuated viruses and a highly desirable feature for an antiviral vaccine.

http://www.ncbi.nlm.nih.gov/pubmed/24606680