Antitumor Virotherapy by Attenuated Measles Virus (MV) - Research - Institut Pasteur

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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Detection and characterization of megasatellites in orthologous and nonorthologous genes of 21 fungal genomes

Structure of the rare archaeal biosphere and seasonal dynamics of active ecotypes in surface coastal waters

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Published in Biology - 28 Mar 2013

Guillerme JB, Gregoire M, Tangy F, Fonteneau JF

Link to Pubmed [PMID] – 24832799

Biology (Basel) 2013;2(2):587-602

Antitumor virotherapy consists of the use of replication-competent viruses to infect and kill tumor cells preferentially, without damaging healthy cells. Vaccine-attenuated strains of measles virus (MV) are good candidates for this approach. Attenuated MV uses the CD46 molecule as a major entry receptor into cells. This molecule negatively regulates the complement system and is frequently overexpressed by cancer cells to escape lysis by the complement system. MV exhibits oncolytic properties in many cancer types in vitro, and in mouse models. Phase I clinical trials using MV are currently underway. Here, we review the state of this therapeutic approach, with a focus on the effects of MV on the antitumor immune response.

Published on: 28 Mar 2013