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© Research
Publication : PloS one

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 27 Oct 2009

Pothlichet J, Burtey A, Kubarenko AV, Caignard G, Solhonne B, Tangy F, Ben-Ali M, Quintana-Murci L, Heinzmann A, Chiche JD, Vidalain PO, Weber AN, Chignard M, Si-Tahar M

Link to Pubmed [PMID] – 19859543

PLoS ONE 2009;4(10):e7582

RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little information is available on RIG-I single-nucleotide polymorphisms (SNPs) presenting a functional impact on the host response.

http://www.ncbi.nlm.nih.gov/pubmed/19859543