Timeline
Asier Sáez-Cirión
Head of Structure
11 Sep 2024
10 Sep 2024
publication
Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection: Learning in vivo dynamics using ex vivo data.
Read more02 Sep 2024
publication
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.
Read more17 Jun 2024
publication
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.
Read more17 Jun 2024
publication
High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells.
Read more01 Jun 2024
publication
Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study.
Read more01 Feb 2024
publication
CD8 + T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy.
Read more11 Jan 2024
publication
Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells.
Read more01 Oct 2023
publication
[A shot of synTac to activate CD8+ T cells cytotoxic specific response against HIV].
Read more06 Jul 2023
publication
Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.
Read more17 May 2023
12 Apr 2023
publication
Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection.
Read more20 Feb 2023
publication
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.
Read more24 Jan 2023
publication
In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control.
Read more01 Jan 2023
publication
Highlights from the Inaugural HIV Reservoirs and Immune Control Conference, October 1st-4th 2023, Malahide Ireland.
Read more02 Oct 2022
publication
Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques.
Read more17 Sep 2022
publication
Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells.
Read more07 Jul 2022
publication
NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections.
Read more13 Apr 2022
11 Apr 2022
publication
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.
Read more05 Apr 2022
publication
Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control.
Read more04 Feb 2022
01 Jan 2022
publication
Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function.
Read more01 Jul 2021
publication
Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort.
Read more05 May 2021
publication
Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection.
Read more18 Apr 2021
24 Feb 2021
publication
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.
Read more01 Jan 2021
publication
CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues.
Read more01 Jan 2021
22 Sep 2020
publication
Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study.
Read more18 Aug 2020
publication
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
Read more26 Jul 2020
publication
The genome-wide methylation profile of CD4+ T cells from HIV-infected individuals identifies distinct patterns associated with disease progression.
Read more01 Jul 2020
publication
Extremely low viral reservoir in treated chronically HIV-1-infected individuals.
Read more01 Jul 2020
publication
Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection.
Read more08 Jun 2020
publication
SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
Read more06 May 2020
publication
Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1.
Read more18 Dec 2019
14 Oct 2019
02 Aug 2019
publication
The proportion of CD57+ cells among effector CD8+ T cells is lower HIV controllers compared to ART treated patients
Read more01 Jul 2019
publication
Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection.
Read more01 Jun 2019
10 May 2019
01 May 2019
publication
HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood
Read more08 Apr 2019
event
Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”
Read more05 Mar 2019
publication
Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection.
Read more04 Mar 2019
26 Feb 2019
publication
Safety of CD34 Hematopoietic Stem Cells and CD4 T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma
Read more31 Jan 2019
01 Jan 2019
21 Nov 2018
event
Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”
Read more18 Sep 2018
event
Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”
Read more27 Aug 2018
22 May 2018
27 Feb 2018
02 Feb 2018
12 Jan 2018
01 Jan 2018
31 Oct 2017
11 Oct 2017
publication
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities
Read more06 Sep 2017
publication
HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION
Read more28 Jun 2017
publication
Clinical and public health implications of acute and early HIV detection and treatment: a scoping review
Read more06 Apr 2017
03 Apr 2017
publication
A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level
Read more15 Mar 2017
publication
Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents.
Read more24 Sep 2016
26 Aug 2016
publication
Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers
Read more19 Aug 2016
publication
Strong Ifitm1 Expression In Cd4 T Cells In Hiv Controllers Is Correlated With Immune Activation
Read more01 Aug 2016
publication
Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset.
Read more11 Jul 2016
publication
International AIDS Society global scientific strategy: towards an HIV cure 2016
Read more27 Apr 2016
publication
Long-term Spontaneous control of HIV-1 relates to low frequency of infected cells and inefficient viral reactivation
Read more12 Feb 2016
01 Jan 2016
publication
Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles.
Read more09 Dec 2015
publication
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report
Read more10 Sep 2015
project
ICISTEM-International Collaboration to guide and investigate the potential for HIV cure by Stem Cell Transplantation
Read more09 Sep 2015
project
Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)
Read more03 Sep 2015
03 Sep 2015
16 Jul 2015
06 Jul 2015
publication
Immunologic and Virologic Progression in HIV Controllers: The Role of Viral “Blips” and Immune Activation in the ANRS CO21 CODEX Study
Read more21 Apr 2015
publication
Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission
Read more18 Feb 2015
publication
Intensive five-drug antiretroviral therapy regimen versus standard triple-drug therapy during primary HIV-1 infection (OPTIPRIM-ANRS 147): a randomised, open-label, phase 3 trial
Read more14 Jan 2015
publication
Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses
Read more12 Jan 2015
publication
Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells
Read more01 Jan 2015
06 Aug 2014
publication
High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection
Read more07 Jul 2014
publication
Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers
Read more01 Apr 2014
publication
Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block
Read more11 Mar 2014
20 Feb 2014
publication
The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
Read more20 Feb 2014
publication
Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients
Read more20 Feb 2014
publication
What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?
Read more17 Jan 2014
publication
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration
Read more01 Jan 2014
publication
Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?
Read more16 Oct 2013
publication
Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
Read more30 Sep 2013
publication
p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
Read more23 Sep 2013
publication
High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers
Read more01 Jul 2013
01 May 2013
29 Mar 2013
publication
CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection
Read more25 Mar 2013
publication
Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion
Read more14 Mar 2013
publication
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
Read more01 Jan 2013
publication
NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers
Read more13 Oct 2012
publication
Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency
Read more11 Oct 2012
publication
Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes
Read more06 Mar 2012
publication
Kidney transplantation in an elite HIV controller: limited impact of immunosuppressive therapy on viro-immunological status
Read more03 Jun 2011
publication
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
Read more21 Apr 2011
publication
CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
Read more01 Nov 2010
publication
Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals
Read more13 May 2010
publication
Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses
Read more15 Jun 2009
publication
Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
Read more23 Apr 2009
publication
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
Read more04 Jan 2008
publication
The characteristic CD8+ T cell response in HIV controllers: an objective to achieve?
Read more03 Jan 2008
publication
Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission
Read more05 Nov 2007
16 May 2007
publication
Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells
Read more11 May 2007
publication
Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)
Read more11 Apr 2007
publication
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
Read more08 Nov 2006
publication
Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks
Read more01 Nov 2006
publication
The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages
Read more01 Jun 2006
publication
Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells
Read more06 Apr 2005
publication
First Dominique Dormont International Conference on “Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections”.
Read more01 Dec 2003
publication
Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation
Read more01 Nov 2003
publication
The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide
Read more01 Jan 2003
publication
Pre-transmembrane sequence of Ebola glycoprotein. Interfacial hydrophobicity distribution and interaction with membranes
Read more19 Aug 2002
02 Apr 2002
publication
Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring
Read more31 Aug 2000
publication
Sphingolipids (Galactosylceramide and Sulfatide) in Lamellar−Hexagonal Phospholipid Phase Transitions and in Membrane Fusion
Read more14 Jul 2000
publication
The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence
Read more01 Jan 2000
publication