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© Charles Dauguet
Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.
Publication : Nature reviews. Immunology

Immunometabolism and HIV-1 pathogenesis: food for thought.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Immunology - 06 Aug 2020

Sáez-Cirión A, Sereti I,

Link to Pubmed [PMID] – 32764670

Link to DOI [DOI] – 10.1038/s41577-020-0381-7

Nat. Rev. Immunol. 2020 Aug; ():

Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life. Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite treatment. There is, therefore, an urgent need to better understand the mechanisms driving HIV-1 pathogenesis and to identify new targets for therapeutic intervention. In the past few years, the decisive role of cellular metabolism in the fate and activity of immune cells has been uncovered, as well as its impact on the outcome of infectious diseases. Emerging evidence suggests that immunometabolism has a key role in HIV-1 pathogenesis. The metabolic pathways of CD4+ T cells and macrophages determine their susceptibility to infection, the persistence of infected cells and the establishment of latency. Immunometabolism also shapes immune responses against HIV-1, and cell metabolic products are key drivers of inflammation during infection. In this Review, we summarize current knowledge of the links between HIV-1 infection and immunometabolism, and we discuss the potential opportunities and challenges for therapeutic interventions.

https://pubmed.ncbi.nlm.nih.gov/32764670