Ligne de temps
Asier Sáez-Cirión
Responsable de Structure
01 févr. 2024
publication
CD8 + T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy.
Lire plus11 janv. 2024
publication
Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells.
Lire plus01 oct. 2023
publication
[A shot of synTac to activate CD8+ T cells cytotoxic specific response against HIV].
Lire plus06 juil. 2023
publication
Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.
Lire plus17 mai 2023
12 avr. 2023
publication
Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection.
Lire plus20 févr. 2023
publication
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.
Lire plus24 janv. 2023
publication
In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control.
Lire plus01 janv. 2023
publication
Highlights from the Inaugural HIV Reservoirs and Immune Control Conference, October 1st-4th 2023, Malahide Ireland.
Lire plus02 oct. 2022
publication
Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques.
Lire plus17 sept. 2022
publication
Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells.
Lire plus07 juil. 2022
publication
NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections.
Lire plus13 avr. 2022
11 avr. 2022
publication
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.
Lire plus05 avr. 2022
publication
Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control.
Lire plus04 févr. 2022
01 janv. 2022
publication
Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function.
Lire plus01 juil. 2021
publication
Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort.
Lire plus05 mai 2021
publication
Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection.
Lire plus18 avr. 2021
24 févr. 2021
publication
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.
Lire plus01 janv. 2021
01 janv. 2021
publication
CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues.
Lire plus22 sept. 2020
publication
Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study.
Lire plus18 août 2020
publication
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
Lire plus26 juil. 2020
publication
The genome-wide methylation profile of CD4+ T cells from HIV-infected individuals identifies distinct patterns associated with disease progression.
Lire plus01 juil. 2020
publication
Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection.
Lire plus01 juil. 2020
publication
Extremely low viral reservoir in treated chronically HIV-1-infected individuals.
Lire plus08 juin 2020
publication
SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
Lire plus06 mai 2020
publication
Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1.
Lire plus18 déc. 2019
14 oct. 2019
02 août 2019
publication
The proportion of CD57+ cells among effector CD8+ T cells is lower HIV controllers compared to ART treated patients
Lire plus01 juil. 2019
publication
Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection.
Lire plus01 juin 2019
10 mai 2019
01 mai 2019
publication
HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood
Lire plus08 avr. 2019
event
Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”
Lire plus05 mars 2019
publication
Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection.
Lire plus04 mars 2019
26 févr. 2019
publication
Safety of CD34 Hematopoietic Stem Cells and CD4 T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma
Lire plus31 janv. 2019
01 janv. 2019
21 nov. 2018
event
Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”
Lire plus18 sept. 2018
event
Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”
Lire plus27 août 2018
22 mai 2018
27 févr. 2018
02 févr. 2018
12 janv. 2018
01 janv. 2018
31 oct. 2017
11 oct. 2017
publication
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities
Lire plus06 sept. 2017
publication
HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION
Lire plus28 juin 2017
publication
Clinical and public health implications of acute and early HIV detection and treatment: a scoping review
Lire plus06 avr. 2017
03 avr. 2017
publication
A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level
Lire plus15 mars 2017
publication
Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents.
Lire plus24 sept. 2016
26 août 2016
publication
Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers
Lire plus19 août 2016
publication
Strong Ifitm1 Expression In Cd4 T Cells In Hiv Controllers Is Correlated With Immune Activation
Lire plus01 août 2016
publication
Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset.
Lire plus11 juil. 2016
publication
International AIDS Society global scientific strategy: towards an HIV cure 2016
Lire plus27 avr. 2016
publication
Long-term Spontaneous control of HIV-1 relates to low frequency of infected cells and inefficient viral reactivation
Lire plus12 févr. 2016
01 janv. 2016
publication
Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles.
Lire plus09 déc. 2015
publication
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report
Lire plus10 sept. 2015
project
ICISTEM-International Collaboration to guide and investigate the potential for HIV cure by Stem Cell Transplantation
Lire plus09 sept. 2015
project
Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)
Lire plus03 sept. 2015
03 sept. 2015
16 juil. 2015
06 juil. 2015
publication
Immunologic and Virologic Progression in HIV Controllers: The Role of Viral “Blips” and Immune Activation in the ANRS CO21 CODEX Study
Lire plus21 avr. 2015
publication
Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission
Lire plus18 févr. 2015
publication
Intensive five-drug antiretroviral therapy regimen versus standard triple-drug therapy during primary HIV-1 infection (OPTIPRIM-ANRS 147): a randomised, open-label, phase 3 trial
Lire plus14 janv. 2015
publication
Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses
Lire plus12 janv. 2015
publication
Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells
Lire plus01 janv. 2015
06 août 2014
publication
High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection
Lire plus07 juil. 2014
publication
Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers
Lire plus01 avr. 2014
publication
Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block
Lire plus11 mars 2014
20 févr. 2014
publication
What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?
Lire plus20 févr. 2014
publication
The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
Lire plus20 févr. 2014
publication
Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients
Lire plus17 janv. 2014
publication
Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration
Lire plus01 janv. 2014
publication
Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?
Lire plus16 oct. 2013
publication
Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
Lire plus30 sept. 2013
publication
p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
Lire plus23 sept. 2013
publication
High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers
Lire plus01 juil. 2013
01 mai 2013
29 mars 2013
publication
CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection
Lire plus25 mars 2013
publication
Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion
Lire plus14 mars 2013
publication
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
Lire plus01 janv. 2013
publication
NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers
Lire plus13 oct. 2012
publication
Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency
Lire plus11 oct. 2012
publication
Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes
Lire plus06 mars 2012
publication
Kidney transplantation in an elite HIV controller: limited impact of immunosuppressive therapy on viro-immunological status
Lire plus03 juin 2011
publication
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
Lire plus21 avr. 2011
publication
CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
Lire plus01 nov. 2010
publication
Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals
Lire plus13 mai 2010
publication
Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses
Lire plus15 juin 2009
publication
Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
Lire plus23 avr. 2009
publication
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
Lire plus04 janv. 2008
publication
The characteristic CD8+ T cell response in HIV controllers: an objective to achieve?
Lire plus03 janv. 2008
publication
Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission
Lire plus05 nov. 2007
16 mai 2007
publication
Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells
Lire plus11 mai 2007
publication
Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)
Lire plus11 avr. 2007
publication
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
Lire plus08 nov. 2006
publication
Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks
Lire plus01 nov. 2006
publication
The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages
Lire plus01 juin 2006
publication
Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells
Lire plus06 avr. 2005
publication
First Dominique Dormont International Conference on “Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections”.
Lire plus01 déc. 2003
publication
Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation
Lire plus01 nov. 2003
publication
The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide
Lire plus01 janv. 2003
publication
Pre-transmembrane sequence of Ebola glycoprotein. Interfacial hydrophobicity distribution and interaction with membranes
Lire plus19 août 2002
02 avr. 2002
publication
Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring
Lire plus31 août 2000
publication
Sphingolipids (Galactosylceramide and Sulfatide) in Lamellar−Hexagonal Phospholipid Phase Transitions and in Membrane Fusion
Lire plus14 juil. 2000
publication
The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence
Lire plus01 janv. 2000
publication