Timeline

Rogerio Amino

Head of Structure

15 Jul 2022

news

A New Drug Target against Malaria

05 Jul 2022

publication

Plasmodium sporozoite disintegration during skin passage limits malaria parasite transmission.

14 Jun 2022

publication

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.

03 Mar 2022

event

PIV department Extraordinary Tandem Seminar : Robert A. SEDER “Scientific and Clinical Development of Malaria Monoclonal Antibodies to Prevent Infection” and Peter CROMPTON “Testing the Safety and Efficacy of Monoclonal Antibodies against Malaria in Africa”

01 Jan 2022

publication

Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against Plasmodium.

01 Jan 2022

publication

Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies.

08 Oct 2021

event

PIV Department seminar – Maria Mota – “The classical epidemiological triad in malaria infections”

09 Apr 2021

publication

Malaria parasites differentially sense environmental elasticity during transmission.

22 Feb 2021

publication

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites.

01 Jan 2021

publication

Calcium in the Backstage of Malaria Parasite Biology.

13 Oct 2020

publication

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

17 Jun 2020

publication

A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of Plasmodium vivax Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic Plasmodium berghei Parasite.

06 Dec 2019

event

HDR “Studies on the life and death of plasmodial parasites. Towards the development of a pre – erythrocytic malaria vaccine. ” Rogerio AMINO

14 May 2019

event

Rosetting of Plasmodium-infected red blood cells: severity factor or escape mechanism ? – Laurent RENIA

27 Feb 2019

publication

Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice.

01 Feb 2019

event

“Malaria parasite formation, motility and attenuation” – Freddy Frischknecht

22 Oct 2018

publication

Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin

10 Oct 2018

publication

TRSP is dispensable for the Plasmodium pre-erythrocytic phase

22 Mar 2018

publication

Nonspecific CD8 T Cells and Dendritic Cells/Macrophages Participate in Formation of CD8 T Cell-Mediated Clusters against Malaria Liver-Stage Infection

20 Mar 2018

publication

Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria

05 Dec 2017

publication

Tissue-specific cellular immune responses to malaria pre-erythrocytic stages

21 Sep 2017

event

Computational Vaccinology Workshop

29 Jun 2017

publication

Yeast lysates carrying the nucleoprotein from measles virus vaccine as a novel subunit vaccine platform to deliver Plasmodium circumsporozoite antigen

15 May 2017

publication

In vivo imaging of pathogen homing to the host tissues

19 Apr 2017

event

“New Malaria Vaccines”

08 Jan 2017

publication

Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses

01 Jan 2017

publication

Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite.

21 Dec 2016

event

“Imaging host-pathogen interactions in the vascular compartment”

06 Oct 2015

publication

Looking for blood

01 Aug 2015

publication

Active migration and passive transport of malaria parasites.

16 Jul 2015

team

Malaria Infection & Immunity

03 Jul 2015

project

Project

04 Feb 2015

publication

Antigen-driven focal inflammatory death of malaria liver stages

22 Nov 2014

publication

Plasmodium berghei histamine-releasing factor favours liver-stage development via inhibition of IL-6 production and associates with a severe outcome of disease

27 Jan 2014

publication

Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens

01 Jan 2014

publication

Classification of T cell movement tracks allows for prediction of cell function.

01 Jan 2014

publication

The role of MACPF proteins in the biology of malaria and other apicomplexan parasites

01 Oct 2013

publication

Looking under the skin: the first steps in malarial infection and immunity

25 Jul 2013

publication

Loss of host cell plasma membrane integrity following cell traversal by Plasmodium sporozoites in the skin

28 May 2013

publication

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages.

01 Jan 2013

publication

Imaging sporozoite cell traversal in the liver of mice

25 Jan 2011

publication

A research agenda for malaria eradication: basic science and enabling technologies

04 Oct 2010

publication

Development of the malaria parasite in the skin of the mammalian host

04 Sep 2008

publication

Hyperbaric oxygen prevents early death caused by experimental cerebral malaria

14 Feb 2008

publication

Host cell traversal is important for progression of the malaria parasite through the dermis to the liver

01 Oct 2007

publication

[A new view of malaria provided by parasite imaging]

01 Jan 2007

publication

In vivo imaging of malaria parasites in the murine liver

01 Jan 2007

publication

Imaging malaria sporozoites in the dermis of the mammalian host

17 Aug 2006

publication

Quantitative imaging of Plasmodium sporozoites in the mammalian host

03 Aug 2006

publication

Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids

22 Jan 2006

publication

Quantitative imaging of Plasmodium transmission from mosquito to mammal

01 Aug 2005

publication

A little guide for advanced search:

A New Drug Target against Malaria

Plasmodium sporozoite disintegration during skin passage limits malaria parasite transmission.

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.

PIV department Extraordinary Tandem Seminar : Robert A. SEDER “Scientific and Clinical Development of Malaria Monoclonal Antibodies to Prevent Infection” and Peter CROMPTON “Testing the Safety and Efficacy of Monoclonal Antibodies against Malaria in Africa”

Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against Plasmodium.

Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies.

PIV Department seminar – Maria Mota – “The classical epidemiological triad in malaria infections”

Malaria parasites differentially sense environmental elasticity during transmission.

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites.

Calcium in the Backstage of Malaria Parasite Biology.

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of Plasmodium vivax Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic Plasmodium berghei Parasite.

HDR “Studies on the life and death of plasmodial parasites. Towards the development of a pre – erythrocytic malaria vaccine. ” Rogerio AMINO

Rosetting of Plasmodium-infected red blood cells: severity factor or escape mechanism ? – Laurent RENIA

Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice.

“Malaria parasite formation, motility and attenuation” – Freddy Frischknecht

Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin

TRSP is dispensable for the Plasmodium pre-erythrocytic phase

Nonspecific CD8 T Cells and Dendritic Cells/Macrophages Participate in Formation of CD8 T Cell-Mediated Clusters against Malaria Liver-Stage Infection

Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria

Tissue-specific cellular immune responses to malaria pre-erythrocytic stages

Computational Vaccinology Workshop

Yeast lysates carrying the nucleoprotein from measles virus vaccine as a novel subunit vaccine platform to deliver Plasmodium circumsporozoite antigen

In vivo imaging of pathogen homing to the host tissues

“New Malaria Vaccines”

Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses

Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite.

“Imaging host-pathogen interactions in the vascular compartment”

Looking for blood

Active migration and passive transport of malaria parasites.

Malaria Infection & Immunity

Project

Antigen-driven focal inflammatory death of malaria liver stages

Plasmodium berghei histamine-releasing factor favours liver-stage development via inhibition of IL-6 production and associates with a severe outcome of disease

Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens

Classification of T cell movement tracks allows for prediction of cell function.

The role of MACPF proteins in the biology of malaria and other apicomplexan parasites

Looking under the skin: the first steps in malarial infection and immunity

Loss of host cell plasma membrane integrity following cell traversal by Plasmodium sporozoites in the skin

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages.

Imaging sporozoite cell traversal in the liver of mice

A research agenda for malaria eradication: basic science and enabling technologies

Development of the malaria parasite in the skin of the mammalian host

Hyperbaric oxygen prevents early death caused by experimental cerebral malaria

Host cell traversal is important for progression of the malaria parasite through the dermis to the liver

[A new view of malaria provided by parasite imaging]

In vivo imaging of malaria parasites in the murine liver

Imaging malaria sporozoites in the dermis of the mammalian host

Quantitative imaging of Plasmodium sporozoites in the mammalian host

Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids

Quantitative imaging of Plasmodium transmission from mosquito to mammal

In vivo imaging of malaria parasites–recent advances and future directions