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© Research
Publication : Science (New York, N.Y.)

Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 03 Aug 2006

Sturm A, Amino R, van de Sand C, Regen T, Retzlaff S, Rennenberg A, Krueger A, Pollok JM, Menard R, Heussler VT

Link to Pubmed [PMID] – 16888102

Science 2006 Sep;313(5791):1287-90

The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as “eat me” signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.

Release of merosomes into the liver sinusoids