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© Research
Publication : PLoS medicine

A research agenda for malaria eradication: basic science and enabling technologies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS medicine - 25 Jan 2011

Link to Pubmed [PMID] – 21311584

PLoS Med. 2011;8(1):e1000399

Today’s malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.

http://www.ncbi.nlm.nih.gov/pubmed/21311584