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© Research
Publication : Comptes rendus biologies

Quantitative imaging of Plasmodium sporozoites in the mammalian host

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus biologies - 17 Aug 2006

Amino R, Thiberge S, Shorte S, Frischknecht F, Ménard R

Link to Pubmed [PMID] – 17067928

C. R. Biol. 2006 Nov;329(11):858-62

Malaria, the disease caused by Plasmodium, kills more than 1 million people annually. Little is known of the pre-erythrocytic phase of the parasite life cycle, i.e., after the sporozoite stage is inoculated in the dermis by a mosquito and before the erythrocyte-infecting stage is released from hepatocytes. We present here a quantitative, real-time analysis of the fate of parasites transmitted in a rodent system. We describe previously unrecognized steps in the parasite’s journey to the liver of the host, which are likely to play an important role in the host immune response.

https://www.ncbi.nlm.nih.gov/pubmed/17067928