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© Research
Event

“Imaging host-pathogen interactions in the vascular compartment”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
09
Jan 2017
Time
10:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Monod
Location
2017-01-09 10:00:00 2017-01-09 11:00:00 Europe/Paris “Imaging host-pathogen interactions in the vascular compartment” Christoph KONRADT – University of Pennsylvania (Philadelphia – USA) An important function of the blood-brain barrier is to exclude pathogens from the central nervous system, but some microorganisms benefit from the ability to enter […] Institut Pasteur, Rue du Docteur Roux, Paris, France Rogerio Amino rogerio.amino@pasteur.fr

About

Christoph KONRADTUniversity of Pennsylvania (Philadelphia – USA)

An important function of the blood-brain barrier is to exclude pathogens from the central nervous system, but some microorganisms benefit from the ability to enter this site. Unexpectedly, analysis of acutely infected mice revealed significant numbers of free parasites in the blood and the presence of infected endothelial cells in the brain vasculature. Intravital imaging demonstrated that replication in and lysis of endothelial cells precedes invasion of the central nervous system, and highlight a novel mechanism for parasite entry to the central nervous system.

Contact : Rogerio AMINO (rogerio.amino@pasteur.fr – Poste : 82 73)

Location

Building: Monod
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France