Timeline

Hélène Strick-Marchand

Group Leader

12 Jul 2024

event

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

02 Apr 2024

publication

A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model.

25 Aug 2023

publication

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

01 Dec 2021

publication

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters.

09 Sep 2021

course

MOOC Viruses and Human Cancers

06 Apr 2021

project

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

06 Mar 2021

publication

Animal Models for Hepatitis B: Does the Supply Meet the Demand?

24 Jun 2020

publication

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers.

01 May 2020

publication

In-vitro and in-vivo models for hepatitis B cure research.

06 Mar 2020

project

Immune profiling to guide host-directed interventions to cure HBV

27 Jan 2020

publication

Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.

01 Jun 2019

publication

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.

01 Aug 2018

publication

A human immune system mouse model with robust lymph node development.

17 Apr 2018

event

“Disruptive Discoveries for HIV, HCV and HBV Infections” by Raymond Schinazi – Virology & Immunology departments joint seminar

01 Mar 2018

publication

Who Defends the Stem Cell’s Citadel?

30 Dec 2017

news

Yin and Yang of IL-2 Therapy

24 Nov 2017

publication

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

31 Aug 2017

publication

Modeling hepatitis virus infections and treatment strategies in humanized mice

26 Apr 2017

event

Raymond Schinazi seminar

06 Apr 2017

publication

A functional DC cross talk promotes human ILC homeostasis in humanized mice.

19 Mar 2017

news

‘ILC-poiesis’: A new model of human ILC differentiation

09 Mar 2017

publication

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

01 Mar 2016

publication

A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.

18 Feb 2016

publication

Progressive developmental restriction, acquisition of left-right identity and cell growth behavior during lobe formation in mouse liver development

21 Oct 2015

project

Pathogen co-infection : HIV, TB, Malaria and HCV

05 Sep 2015

project

Humanized mouse models for studying viral hepatitis

16 Jul 2015

team

Group: Humanized mice for infectious disease modeling

11 May 2015

team

Innate Immunity

10 Feb 2015

publication

Towards an HBV cure: state-of-the-art and unresolved questions–report of the ANRS workshop on HBV cure

01 Jan 2014

publication

Animal models to test hiPS-derived hepatocytes in the context of inherited metabolic liver diseases.

01 Oct 2012

publication

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice

02 Jun 2012

publication

Production of hepatitis B defective particles is dependent on liver status

12 Oct 2011

publication

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

30 Aug 2011

publication

Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice

25 Jul 2011

publication

Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

28 Mar 2011

publication

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo

01 May 2010

publication

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

23 Jul 2009

publication

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

01 Dec 2008

publication

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer

15 Aug 2008

publication

Lymphocytes support oval cell-dependent liver regeneration

05 Jun 2008

publication

Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells

12 Sep 2007

publication

Gamma c cytokines condition the progressive differentiation of CD4+ T cells

19 Jul 2007

publication

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers

01 Sep 2006

publication

Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo

01 Dec 2004

publication

Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver

20 May 2004

publication

Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes

01 Nov 2003

publication

Isolation and characterization of mouse hepatic stem cells in vitro

01 Jan 2003

publication

Embryonic liver cells and permanent lines as models for hepatocyte and bile duct cell differentiation

01 Oct 2002

publication

A little guide for advanced search:

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model.

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters.

MOOC Viruses and Human Cancers

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

Animal Models for Hepatitis B: Does the Supply Meet the Demand?

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers.

In-vitro and in-vivo models for hepatitis B cure research.

Immune profiling to guide host-directed interventions to cure HBV

Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.

A human immune system mouse model with robust lymph node development.

“Disruptive Discoveries for HIV, HCV and HBV Infections” by Raymond Schinazi – Virology & Immunology departments joint seminar

Who Defends the Stem Cell’s Citadel?

Yin and Yang of IL-2 Therapy

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

Modeling hepatitis virus infections and treatment strategies in humanized mice

Raymond Schinazi seminar

A functional DC cross talk promotes human ILC homeostasis in humanized mice.

‘ILC-poiesis’: A new model of human ILC differentiation

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.

Progressive developmental restriction, acquisition of left-right identity and cell growth behavior during lobe formation in mouse liver development

Pathogen co-infection : HIV, TB, Malaria and HCV

Humanized mouse models for studying viral hepatitis

Group: Humanized mice for infectious disease modeling

Innate Immunity

Towards an HBV cure: state-of-the-art and unresolved questions–report of the ANRS workshop on HBV cure

Animal models to test hiPS-derived hepatocytes in the context of inherited metabolic liver diseases.

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice

Production of hepatitis B defective particles is dependent on liver status

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice

Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer

Lymphocytes support oval cell-dependent liver regeneration

Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells

Gamma c cytokines condition the progressive differentiation of CD4+ T cells

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers

Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo

Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver

Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes

Isolation and characterization of mouse hepatic stem cells in vitro

Embryonic liver cells and permanent lines as models for hepatocyte and bile duct cell differentiation

Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos