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Scientific Fields
Diseases
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Published in European journal of immunology - 19 Mar 2019

Masse-Ranson G, Dusséaux M, Fiquet O, Darche S, Boussand M, Li Y, Lopez-Lastra S, Legrand N, Corcuff E, Toubert A, Centlivre M, Bruel T, Spits H, Schwartz O, Lévy Y, Strick-Marchand H, Di Santo JP

Link to Pubmed [PMID] – 30888052

Eur. J. Immunol. 2019 Mar;

Human Immune System (HIS) mouse models provide a robust in vivo platform to study human immunity. Nevertheless, the signals that guide human lymphocyte differentiation in HIS mice remain poorly understood. Here, we have developed a novel Balb/c Rag2 Il2rg Sirpa (BRGS) HIS mouse model expressing human HLA-A2 and -DR2 transgenes (BRGSA2DR2). When comparing BRGS and BRGSA2DR2 HIS mice engrafted with human CD34 stem cells, a more rapid emergence of T cells in the circulation of hosts bearing human HLA was shown, which may reflect a more efficient human T cell development in the mouse thymus. Development of CD4 and CD8 T cells was accelerated in BRGSA2DR2 HIS mice and generated more balanced B and T cell compartments in peripheral lymphoid organs. Both B and T cell function appeared enhanced in the presence of human HLA transgenes with higher levels of class switched Ig, increased percentages of polyfunctional T cells and clear evidence for antigen-specific T cell responses following immunization. Taken together, the presence of human HLA class I and II molecules can improve multiple aspects of human B and T cell homeostasis and function in the BRGS-based HIS mouse model. This article is protected by copyright. All rights reserved.

https://www.ncbi.nlm.nih.gov/pubmed/30888052