Timeline

Nadia Izadi-Pruneyre

Head of Structure

05 Jul 2024

publication

Structure and Dynamics of Type 4a Pili and Type 2 Secretion System Endopili

01 Apr 2024

publication

Mechanism of action of phthalazinone derivatives against rabies virus.

07 Feb 2024

news

Des moteurs moléculaires produisent l’énergie nécessaire pour nourrir les bactéries

07 Feb 2024

news

Des moteurs moléculaires produisent l’énergie nécessaire pour nourrir les bactéries

01 Feb 2024

publication

Bonds and bytes: The odyssey of structural biology

06 Jan 2024

publication

Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.

23 Nov 2023

publication

The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking.

12 Nov 2023

publication

A poly-proline II helix in YadA from Yersinia enterocolitica serotype O:9 facilitates heparin binding through electrostatic interactions.

07 Nov 2023

publication

Structural Analysis of Proteins from Bacterial Secretion Systems and Their Assemblies by NMR Spectroscopy

25 Aug 2023

event

DBSC workshop “Optimal Prediction of Protein Complex Structures with AlphaFold Made Easy” on September 26th

02 Feb 2023

publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

01 Feb 2023

news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

27 Jan 2023

event

NMR: a tool for biology XIIIth

11 Sep 2022

project

Energir: Energy dependent iron import by Gram-negative bacteria

28 Apr 2022

publication

Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system.

13 Apr 2022

publication

Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog

16 Mar 2022

event

Half-day Latest innovations and Applications in CryoEM& CryoET

01 Oct 2021

publication

1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

28 Sep 2021

project

ANR OM-LipAsy: Outer membrane lipid asymmetry in Veillonella parvula, an atypical diderm Firmicute

11 Sep 2021

publication

Computational and biochemical analysis of type IV pilus dynamics and stability.

14 Jul 2021

publication

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.

22 Jun 2020

event

NMR: a tool for Biology XIIth

20 Dec 2019

event

Department of Structural Biology and Chemistry seminar: Dr. Olivier Lambert, Antibiotic resistance and contribution of Multidrug Efflux Pumps: Structural and functional insights.

29 Nov 2019

publication

Structure and function of minor pilins of type IV pili.

31 Jul 2019

project

Synergy_T2SS

09 Jul 2019

news

Post-doc available

23 May 2019

publication

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

09 Apr 2019

publication

Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.

26 Jan 2019

event

11th Conference “NMR: a tool for Biology”, 28-30 Jan 2019

24 Jan 2019

patent

Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987

18 Dec 2018

publication

Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR.

06 Apr 2018

event

Seminar of the Department of Structural Biology and Chemistry

05 Apr 2018

event

Inhibiting Chromatin Assembly by Targeting Histone Chaperones

09 Mar 2018

project

Protein synthesis machinery of Trypanosomatid as a therapeutic target

27 Dec 2017

event

Dr. OCHSENBEIN Françoise – “Inhibiting Chromatin Assembly by Targeting Histone Chaperones” (CANCELLED)

28 Nov 2017

project

ViBrANT (Viral and Bacterial Adhesin Network Training)

01 Oct 2017

publication

1H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxytoca type 2 secretion system.

27 May 2016

publication

Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach.

09 Sep 2015

tool

Nuclear Magnetic Resonance spectrometers

31 Aug 2015

project

Binding mode of promising antituberculosis clinical compounds to their bacterial target

28 Aug 2015

team

Bacterial transmembrane systems

22 Jul 2015

project

FiberSpace

07 Jul 2015

project

Bacterial Transmembrane Signaling

01 Jun 2015

publication

A tribute to Cécile Wandersman

15 Sep 2014

department

Structural Biology and Chemistry

11 Apr 2014

publication

Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR

19 Mar 2013

publication

The structure of HasB reveals a new class of TonB protein fold

15 Dec 2012

publication

¹H, ¹⁵N and ¹³C resonance assignments of PpdD, a type IV pilin from enterohemorrhagic Escherichia coli

14 Mar 2012

publication

(1)H, (13)C and (15)N resonance assignments of the periplasmic signalling domain of HasR, a TonB-dependent outer membrane heme transporter

11 Feb 2009

publication

Mapping the interaction between the hemophore HasA and its outer membrane receptor HasR using CRINEPT-TROSY NMR spectroscopy.

14 Jan 2009

publication

Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex

28 Mar 2008

publication

Modulation by substrates of the interaction between the HasR outer membrane receptor and its specific TonB-like protein, HasB

19 Jan 2008

publication

Novel heme ligand displacement by CO in the soluble hemophore HasA and its proximal ligand mutants: implications for heme uptake and release

04 Dec 2007

publication

Comparative analysis of structural and dynamic properties of the loaded and unloaded hemophore HasA: functional implications

03 Nov 2007

publication

(1)H, (13)C and (15)N resonance assignments of the C-terminal domain of HasB, a specific TonB like protein, from Serratia marcescens

04 May 2007

publication

Mutagenesis and molecular modeling reveal three key extracellular loops of the membrane receptor HasR that are involved in hemophore HasA binding

25 Oct 2006

publication

The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligand

14 Jun 2006

publication

The heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site

01 Oct 2003

publication

Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions

01 Oct 2003

publication

Role of the tyrosine corner motif in the stability of neocarzinostatin

16 Sep 2003

publication

Thermodynamics of heme binding to the HasA(SM) hemophore: effect of mutations at three key residues for heme uptake

01 Nov 2001

publication

Key interactions in the immunoglobulin-like structure of apo-neocarzinostatin: evidence from nuclear magnetic resonance relaxation data and molecular dynamics simulations

01 Nov 2000

publication

Functional aspects of the heme bound hemophore HasA by structural analysis of various crystal forms

01 Mar 2000

publication

Simple and accurate determination of global tau(R) in proteins using (13)C or (15)N relaxation data

01 Jan 2000

publication

Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease

01 Jun 1999

publication

Backbone NMR assignment and secondary structure of the 19 kDa hemophore HasA

01 Jun 1999

publication

The crystal structure of HasA, a hemophore secreted by Serratia marcescens

01 Apr 1999

publication

NMR studies of the C-terminal secretion signal of the haem-binding protein, HasA

10 Jun 1997

publication

A little guide for advanced search:

Structure and Dynamics of Type 4a Pili and Type 2 Secretion System Endopili

Mechanism of action of phthalazinone derivatives against rabies virus.

Des moteurs moléculaires produisent l’énergie nécessaire pour nourrir les bactéries

Des moteurs moléculaires produisent l’énergie nécessaire pour nourrir les bactéries

Bonds and bytes: The odyssey of structural biology

Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.

The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking.

A poly-proline II helix in YadA from Yersinia enterocolitica serotype O:9 facilitates heparin binding through electrostatic interactions.

Structural Analysis of Proteins from Bacterial Secretion Systems and Their Assemblies by NMR Spectroscopy

DBSC workshop “Optimal Prediction of Protein Complex Structures with AlphaFold Made Easy” on September 26th

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

NMR: a tool for biology XIIIth

Energir: Energy dependent iron import by Gram-negative bacteria

Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system.

Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog

Half-day Latest innovations and Applications in CryoEM& CryoET

1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

ANR OM-LipAsy: Outer membrane lipid asymmetry in Veillonella parvula, an atypical diderm Firmicute

Computational and biochemical analysis of type IV pilus dynamics and stability.

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.

NMR: a tool for Biology XIIth

Department of Structural Biology and Chemistry seminar: Dr. Olivier Lambert, Antibiotic resistance and contribution of Multidrug Efflux Pumps: Structural and functional insights.

Structure and function of minor pilins of type IV pili.

Synergy_T2SS

Post-doc available

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.

11th Conference “NMR: a tool for Biology”, 28-30 Jan 2019

Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987

Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR.

Seminar of the Department of Structural Biology and Chemistry

Inhibiting Chromatin Assembly by Targeting Histone Chaperones

Protein synthesis machinery of Trypanosomatid as a therapeutic target

Dr. OCHSENBEIN Françoise – “Inhibiting Chromatin Assembly by Targeting Histone Chaperones” (CANCELLED)

ViBrANT (Viral and Bacterial Adhesin Network Training)

1H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxytoca type 2 secretion system.

Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach.

Nuclear Magnetic Resonance spectrometers

Binding mode of promising antituberculosis clinical compounds to their bacterial target

Bacterial transmembrane systems

FiberSpace

Bacterial Transmembrane Signaling

A tribute to Cécile Wandersman

Structural Biology and Chemistry

Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR

The structure of HasB reveals a new class of TonB protein fold

¹H, ¹⁵N and ¹³C resonance assignments of PpdD, a type IV pilin from enterohemorrhagic Escherichia coli

(1)H, (13)C and (15)N resonance assignments of the periplasmic signalling domain of HasR, a TonB-dependent outer membrane heme transporter

Mapping the interaction between the hemophore HasA and its outer membrane receptor HasR using CRINEPT-TROSY NMR spectroscopy.

Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex

Modulation by substrates of the interaction between the HasR outer membrane receptor and its specific TonB-like protein, HasB

Novel heme ligand displacement by CO in the soluble hemophore HasA and its proximal ligand mutants: implications for heme uptake and release

Comparative analysis of structural and dynamic properties of the loaded and unloaded hemophore HasA: functional implications

(1)H, (13)C and (15)N resonance assignments of the C-terminal domain of HasB, a specific TonB like protein, from Serratia marcescens

Mutagenesis and molecular modeling reveal three key extracellular loops of the membrane receptor HasR that are involved in hemophore HasA binding

The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligand

The heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site

Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions

Role of the tyrosine corner motif in the stability of neocarzinostatin

Thermodynamics of heme binding to the HasA(SM) hemophore: effect of mutations at three key residues for heme uptake

Key interactions in the immunoglobulin-like structure of apo-neocarzinostatin: evidence from nuclear magnetic resonance relaxation data and molecular dynamics simulations

Functional aspects of the heme bound hemophore HasA by structural analysis of various crystal forms

Simple and accurate determination of global tau(R) in proteins using (13)C or (15)N relaxation data

Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease

Backbone NMR assignment and secondary structure of the 19 kDa hemophore HasA

The crystal structure of HasA, a hemophore secreted by Serratia marcescens

NMR studies of the C-terminal secretion signal of the haem-binding protein, HasA

Purification and characterization of an extracellular heme-binding protein, HasA, involved in heme iron acquisition