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© Research
Publication : Nature structural biology

The crystal structure of HasA, a hemophore secreted by Serratia marcescens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature structural biology - 01 Jun 1999

Arnoux P, Haser R, Izadi N, Lecroisey A, Delepierre M, Wandersman C, Czjzek M

Link to Pubmed [PMID] – 10360351

Nat. Struct. Biol. 1999 Jun;6(6):516-20

Free iron availability is strongly limited in vertebrate hosts, making the iron acquisition by siderophores inappropriate. Pathogenic bacteria have developed various ways to use the host’s iron from iron-containing proteins. Serratia marcescens can use the iron from hemoglobin through the secretion of a hemophore called HasA, which takes up the heme from hemoglobin and shuttles it to the receptor HasR, which in turn, releases heme into the bacterium. We report here the first crystal structure of such a hemophore, bound to a heme group at two different pH values and at a resolution of 1.9 A. The structure reveals a new original fold and suggests a hypothetical mechanism for both heme uptake and release.

http://www.ncbi.nlm.nih.gov/pubmed/10360351