Timeline

David Bikard
Head of Structure
30 Sep 2019
event

Microbiology seminar: “CRISPR-Cas: acquired immunity in prokaryotes”

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12 Sep 2019
publication

Cell-wall synthases contribute to bacterial cell-envelope integrity by actively repairing defects

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01 Aug 2019
publication

Gene silencing with CRISPRi in bacteria and optimization of dCas9 expression levels

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26 Jul 2019
tool

crispr.pasteur.fr

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13 May 2019
publication

Editing the microbiome the CRISPR way

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13 May 2019
publication

A matter of background: DNA repair pathways as a possible cause for the sparse distribution of CRISPR-Cas systems in bacteria

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20 Feb 2019
event

130 Years of Institut Pasteur: Celebrating Science

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07 Nov 2018
publication

Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors

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15 May 2018
publication

A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9

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08 Mar 2018
publication

Tuning dCas9’s ability to block transcription enables robust, noiseless knockdown of bacterial genes

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12 Dec 2017
publication

Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria

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27 Nov 2017
project

ERC starting grant – CRISPAIR: Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools

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15 Aug 2017
publication

PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data

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01 Jun 2017
publication

Using CRISPR-Cas systems as antimicrobials

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28 Mar 2017
publication

Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance

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10 Mar 2017
event

From phage defense to biotechnological tools: CRISPR and more

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14 Feb 2017
software

PhageTerm

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05 Jan 2017
publication

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response

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23 Sep 2016
project

Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains

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17 Sep 2016
publication

A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages

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08 Apr 2016
publication

Consequences of Cas9 cleavage in the chromosome of Escherichia coli

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27 Jul 2015
publication

Adapting to new threats: the generation of memory by CRISPR-Cas immune systems

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02 Jul 2015
project

Studying and fighting pathogenic bacteria with the help of CRISPR

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11 May 2015
team

Synthetic Biology

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11 May 2015
team

Bacterial Genome Plasticity

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18 Feb 2015
publication

Cas9 specifies functional viral targets during CRISPR-Cas adaptation

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05 Oct 2014
publication

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

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31 Aug 2014
publication

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

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02 Dec 2013
publication

The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites

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01 Nov 2013
publication

Control of gene expression by CRISPR-Cas systems

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12 Jun 2013
publication

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

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29 Jan 2013
publication

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

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01 Jan 2013
publication

Shuffling of DNA cassettes in a synthetic integron

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16 Aug 2012
publication

CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection

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11 Nov 2011
publication

Innate and adaptive immunity in bacteria: mechanisms of programmed genetic variation to fight bacteriophages

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01 Dec 2010
publication

Folded DNA in action: hairpin formation and biological functions in prokaryotes

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13 Jul 2010
publication

Cellular pathways controlling integron cassette site folding

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09 Jun 2010
publication

The synthetic integron: an in vivo genetic shuffling device

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04 Sep 2009
publication

Structural features of single-stranded integron cassette attC sites and their role in strand selection

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01 May 2008
publication

[First French team success during iGEM synthetic biology competition]

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