Ligne de temps
David Bikard
Responsable de Structure
22 oct. 2024
publication
Delivery of functional Cas:DNA nucleoprotein complexes into recipient bacteria through a type IV secretion system.
Lire plus07 août 2024
01 août 2024
24 juin 2024
event
Seminar Joe Bondy-Denomy “A bacteriophage that evades immune nucleases by pretending to be a eukaryote”
Lire plus27 mai 2024
event
Microbiology dpt seminar: Vincent Libis (Elis lab, Paris, France) : “Scalable discovery of microbial secondary metabolites through synthetic biology” ; Friday 7 June @ 11:30am ; Auditorium François Jacob.
Lire plus07 mai 2024
publication
Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans.
Lire plus25 avr. 2024
publication
Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity.
Lire plus04 mars 2024
01 mars 2024
event
Dpt of Computational Biology & SPAIS joint seminar – ATC-AI : Inferring and Characterizing Cellular and Neural Dynamics with Geometric and Topological Deep Learning
Lire plus12 janv. 2024
publication
Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems.
Lire plus01 nov. 2023
publication
Computational design of novel Cas9 PAM-interacting domains using evolution-based modelling and structural quality assessment.
Lire plus01 juin 2023
publication
Machine learning for evolutionary-based and physics-inspired protein design: Current and future synergies.
Lire plus25 avr. 2023
17 mars 2023
publication
Cas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity.
Lire plus11 mai 2022
21 mars 2022
news
Congratulation to David Bikard for being awarded an ERC Consolidator Granthttps://www.imt.fr/wp-content/uploads/2015/02/201501_ERC.jpg
Lire plus18 mars 2022
17 mars 2022
project
ERC CoG: In situ genetic perturbation of gut bacteria with engineered phage vectors and CRISPR
Lire plus02 févr. 2022
15 sept. 2021
publication
High‑throughput identification of viral termini and packaging mechanisms in virome datasets using PhageTermVirome
Lire plus23 juin 2021
12 juin 2021
publication
Improving sequence-based modeling of protein families using secondary structure quality assessment.
Lire plus17 mai 2021
13 avr. 2021
publication
Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane, promoting fitness upon envelope stress.
Lire plus01 mars 2021
publication
The impact of genetic diversity on gene essentiality within the Escherichia coli species.
Lire plus26 févr. 2021
07 déc. 2020
event
Microbiology DPT Work in Progress “Understanding the sequence determinants of guide RNAs for the activity of dCas9 in bacteria”, Alicia Calvo-Villamañán
Lire plus01 juil. 2020
publication
Structure-specific DNA recombination sites: Design, validation, and machine learning–based refinement
Lire plus30 avr. 2020
publication
On-target activity predictions enable improved CRISPR-dCas9 screens in bacteria
Lire plus24 janv. 2020
publication
Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile genetic elements
Lire plus06 janv. 2020
publication
Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects
Lire plus30 sept. 2019
01 août 2019
publication
Gene silencing with CRISPRi in bacteria and optimization of dCas9 expression levels
Lire plus26 juil. 2019
13 mai 2019
13 mai 2019
publication
A matter of background: DNA repair pathways as a possible cause for the sparse distribution of CRISPR-Cas systems in bacteria
Lire plus20 févr. 2019
07 nov. 2018
publication
Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors
Lire plus15 mai 2018
08 mars 2018
publication
Tuning dCas9’s ability to block transcription enables robust, noiseless knockdown of bacterial genes
Lire plus12 déc. 2017
27 nov. 2017
project
ERC starting grant – CRISPAIR: Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools
Lire plus15 août 2017
publication
PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data
Lire plus01 juin 2017
28 mars 2017
publication
Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance.
Lire plus10 mars 2017
14 févr. 2017
05 janv. 2017
publication
Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response
Lire plus23 sept. 2016
project
Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains
Lire plus17 sept. 2016
publication
A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages
Lire plus08 avr. 2016
27 juil. 2015
publication
Adapting to new threats: the generation of memory by CRISPR-Cas immune systems
Lire plus02 juil. 2015
11 mai 2015
11 mai 2015
18 févr. 2015
05 oct. 2014
31 août 2014
publication
Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting
Lire plus01 févr. 2014
publication
The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites.
Lire plus01 nov. 2013
12 juin 2013
publication
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
Lire plus29 janv. 2013
01 janv. 2013
16 août 2012
publication
CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection
Lire plus11 nov. 2011
publication
Innate and adaptive immunity in bacteria: mechanisms of programmed genetic variation to fight bacteriophages
Lire plus09 juin 2010
01 mai 2008