Timeline

Lisa Chakrabarti

Group Leader

21 Nov 2024

project

Development of a lymphoid organ-on-chip

07 Oct 2024

publication

Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting.

01 Sep 2024

publication

Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1.

05 Jan 2024

event

Group de Reflexion SIDA (GRS) seminar: “New insights in the regulation of HIV expression and latency”

01 Dec 2023

publication

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1.

01 Nov 2023

publication

Neutralization of African enterovirus A71 genogroups by antibodies to canonical genogroups.

10 Oct 2023

event

Groupe de Réflexion SIDA (GRS) meeting: “HIV sensing, nuclear import, and latency”

01 Mar 2023

publication

Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants.

01 Jan 2023

publication

Divergent adaptive immune responses define two types of long COVID.

02 Nov 2022

event

Groupe de Reflexion SIDA (GRS) meeting: “Role of membraneless organelles in viral replication”

19 Sep 2022

publication

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.

21 Jul 2022

event

Groupe de Reflexion SIDA (GRS) seminar: “Functional and structural studies of the T cell response against two major human viruses: HIV-1 and SARS-CoV-2”

04 Jul 2022

publication

A close shave: How SARS-CoV-2 induces the loss of cilia.

13 Apr 2022

publication

Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX-a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine.

26 Jan 2022

publication

Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.

01 Jan 2022

publication

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

15 Dec 2021

publication

SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.

13 Oct 2021

event

Groupe de Réflexion SIDA (GRS) meeting: “The cytoskeleton and viruses”

21 Sep 2021

publication

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

22 Jul 2021

news

SARS-CoV-2 : induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

16 Jul 2021

publication

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.

01 Jun 2021

publication

Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination.

07 Jan 2021

publication

Role of CD4+ T Cells in the Control of Viral Infections: Recent Advances and Open Questions.

01 Feb 2020

publication

Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection.

10 May 2019

event

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of HIV antigen presentation”

09 Apr 2019

publication

A role for antibodies in natural HIV control

08 Apr 2019

event

Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”

01 Apr 2019

project

Organ-on-Chip Center

04 Mar 2019

event

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of restriction of viral entry”

31 Jan 2019

project

Archive of the Group for AIDS Research

21 Nov 2018

event

Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”

18 Sep 2018

event

Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”

19 Jun 2018

publication

CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis

08 Jun 2018

publication

CD4 T cell-mediated HLA class II cross-restriction in HIV controllers

22 May 2018

event

Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies”

08 May 2018

publication

A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers

27 Feb 2018

event

GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”

02 Feb 2018

event

Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”

31 Oct 2017

event

Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”

09 Oct 2017

publication

DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers

06 Apr 2017

event

GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”

25 Apr 2016

publication

Public T cell receptors confer high-avidity CD4 responses to HIV controllers

12 Feb 2016

project

Group for AIDS Research

11 Feb 2016

publication

TCR clonotypes: molecular determinants of T-cell efficacy against HIV

21 Sep 2015

project

Dynamics of high avidity CD4+ T cell clonotypes directed at HIV-1 capsid

21 Sep 2015

project

Characterization of the TCR signature induced by candidate HIV vaccines

21 Sep 2015

project

T follicular helper (Tfh) function in HIV Controllers

16 Jul 2015

team

Group: Lisa Chakrabarti

03 Jul 2015

project

Viral Pathogenesis Unit’s Project

06 Feb 2015

publication

[IRIS: a paradoxical inflammatory reaction in patients treated simultaneously for tuberculosis and HIV]

17 Jul 2014

publication

Biomarkers of CD4+ T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome

17 Jul 2013

publication

Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles

30 Jan 2013

publication

Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia

25 Jul 2012

publication

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term

24 Sep 2011

publication

HIV infection perturbs interleukin-7 signaling at the step of STAT5 nuclear relocalization

04 Aug 2011

publication

HIV controllers: a multifactorial phenotype of spontaneous viral suppression

21 Apr 2011

publication

CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory

01 Mar 2011

publication

[Role of CD4 lymphocytes in the efficient immune response of HIV controllers]

01 Aug 2010

publication

Immune mechanisms of HIV control

26 Feb 2010

publication

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

01 Jan 2010

publication

Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway

28 Dec 2009

publication

Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4

19 Jun 2009

publication

HIV infection impairs CCR7-dependent T-cell chemotaxis independent of CCR7 expression

15 May 2009

publication

A programmed switch from IL-15- to IL-2-dependent activation in human NK cells

10 Oct 2007

publication

Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study

15 Jun 2007

publication

Induction of potent local cellular immunity with low dose X4 SHIV(SF33A) vaginal exposure

08 Nov 2006

publication

Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks

15 Dec 2004

publication

CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes

01 Jan 2004

publication

The paradox of simian immunodeficiency virus infection in sooty mangabeys: active viral replication without disease progression

01 Jan 2003

publication

A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replication

16 May 2002

publication

Interaction of HIV-1 integrase with DNA repair protein hRad18

01 Feb 2002

publication

Properties of the surface envelope glycoprotein associated with virulence of simian-human immunodeficiency virus SHIV(SF33A) molecular clones

10 Aug 2001

publication

A divergent simian immunodeficiency virus from sooty mangabey with an atypical Tat-TAR structure

01 Aug 2000

publication

Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys

01 Feb 2000

publication

Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection

01 May 1998

publication

Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease

01 Nov 1996

publication

Interferon-gamma expression in macaque lymph nodes during primary infection with simian immunodeficiency virus

01 Sep 1996

publication

The relationship between the interferon alpha response and viral burden in primary SIV infection

01 Mar 1996

publication

Cytokine patterns and viral load in lymph nodes during the early stages of SIV infection

01 Dec 1995

publication

Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection

10 Nov 1995

publication

Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus

01 Nov 1995

publication

Highly attenuated SIVmac142 is immunogenic but does not protect against SIVmac251 challenge

01 Dec 1994

publication

Early stages of feline immunodeficiency virus infection in lymph nodes and spleen

01 Oct 1994

publication

Cytokine patterns in lymph nodes during the early stages of simian immunodeficiency virus infection

01 Oct 1994

publication

Variable course of primary simian immunodeficiency virus infection in lymph nodes: relation to disease progression

01 Jun 1994

publication

Early stages of simian immunodeficiency virus infection in lymph nodes. Evidence for high viral load and successive populations of target cells

01 May 1994

publication

Early events in lymph nodes during infection with SIV and FIV

01 Feb 1994

publication

Kinetics of primary SIV infection in lymph nodes

01 Jan 1993

publication

Target cells during early SIV encephalopathy

01 Apr 1992

publication

Comparison of early and late feline immunodeficiency virus encephalopathies

01 Dec 1991

publication

Early viral replication in the brain of SIV-infected rhesus monkeys

01 Jun 1991

publication

Early SIV encephalopathy

01 Oct 1989

publication

The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity

06 Aug 1987

publication

A little guide for advanced search:

Development of a lymphoid organ-on-chip

Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting.

Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1.

Group de Reflexion SIDA (GRS) seminar: “New insights in the regulation of HIV expression and latency”

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1.

Neutralization of African enterovirus A71 genogroups by antibodies to canonical genogroups.

Groupe de Réflexion SIDA (GRS) meeting: “HIV sensing, nuclear import, and latency”

Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants.

Divergent adaptive immune responses define two types of long COVID.

Groupe de Reflexion SIDA (GRS) meeting: “Role of membraneless organelles in viral replication”

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.

Groupe de Reflexion SIDA (GRS) seminar: “Functional and structural studies of the T cell response against two major human viruses: HIV-1 and SARS-CoV-2”

A close shave: How SARS-CoV-2 induces the loss of cilia.

Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX-a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine.

Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.

Groupe de Réflexion SIDA (GRS) meeting: “The cytoskeleton and viruses”

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

SARS-CoV-2 : induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.

Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination.

Role of CD4+ T Cells in the Control of Viral Infections: Recent Advances and Open Questions.

Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection.

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of HIV antigen presentation”

A role for antibodies in natural HIV control

Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”

Organ-on-Chip Center

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of restriction of viral entry”

Archive of the Group for AIDS Research

Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”

Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”

CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis

CD4 T cell-mediated HLA class II cross-restriction in HIV controllers

Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies”

A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers

GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”

Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”

Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”

DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers

GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”

Public T cell receptors confer high-avidity CD4 responses to HIV controllers

Group for AIDS Research

TCR clonotypes: molecular determinants of T-cell efficacy against HIV

Dynamics of high avidity CD4+ T cell clonotypes directed at HIV-1 capsid

Characterization of the TCR signature induced by candidate HIV vaccines

T follicular helper (Tfh) function in HIV Controllers

Group: Lisa Chakrabarti

Viral Pathogenesis Unit’s Project

[IRIS: a paradoxical inflammatory reaction in patients treated simultaneously for tuberculosis and HIV]

Biomarkers of CD4+ T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome

Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles

Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term

HIV infection perturbs interleukin-7 signaling at the step of STAT5 nuclear relocalization

HIV controllers: a multifactorial phenotype of spontaneous viral suppression

CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory

[Role of CD4 lymphocytes in the efficient immune response of HIV controllers]

Immune mechanisms of HIV control

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway

Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4

HIV infection impairs CCR7-dependent T-cell chemotaxis independent of CCR7 expression

A programmed switch from IL-15- to IL-2-dependent activation in human NK cells

Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study

Induction of potent local cellular immunity with low dose X4 SHIV(SF33A) vaginal exposure

Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks

CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes

The paradox of simian immunodeficiency virus infection in sooty mangabeys: active viral replication without disease progression

A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replication

Interaction of HIV-1 integrase with DNA repair protein hRad18

Properties of the surface envelope glycoprotein associated with virulence of simian-human immunodeficiency virus SHIV(SF33A) molecular clones

A divergent simian immunodeficiency virus from sooty mangabey with an atypical Tat-TAR structure

Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys

Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection

Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease

Interferon-gamma expression in macaque lymph nodes during primary infection with simian immunodeficiency virus

The relationship between the interferon alpha response and viral burden in primary SIV infection

Cytokine patterns and viral load in lymph nodes during the early stages of SIV infection