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© Charles DAUGUET, Institut Pasteur
HIV particles
Publication : Médecine sciences : M/S

[IRIS: a paradoxical inflammatory reaction in patients treated simultaneously for tuberculosis and HIV]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Médecine sciences : M/S - 06 Feb 2015

Chakrabarti LA, Lortholary O

Link to Pubmed [PMID] – 25658731

Med Sci (Paris) 2015 Jan;31(1):53-9

Co-infection with Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) represents a major threat to public health worldwide. The treatment of patients coinfected by Mtb and HIV is often complicated by the occurrence of an immune reconstitution inflammatory syndrome (IRIS), resulting in the unexpected resumption of tuberculosis symptoms after the initiation of antiretroviral therapy. IRIS is associated with a rapid reconstitution of CD4(+) T cell responses specific for Mtb, which is promoted by the control of HIV replication and a high concentration of available interleukin-7. Macrophages, whose activity is suddenly stimulated by CD4(+) T cell help, respond by an exacerbated inflammatory response in Mtb-rich tissues. A major research objective remains to identify biomarkers which could allow a reliable prediction of IRIS occurrence, in order to optimize medical care for the many patients affected by both HIV and tuberculosis in resource-limited settings.

http://www.ncbi.nlm.nih.gov/pubmed/25658731