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© Charles DAUGUET, Institut Pasteur
HIV particles
Publication : Journal of medical primatology

Early SIV encephalopathy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of medical primatology - 01 Jun 1991

Hurtrel B, Chakrabarti L, Hurtrel M, Maire MA, Dormont D, Montagnier L

Link to Pubmed [PMID] – 1942006

J. Med. Primatol. 1991 Jun;20(4):159-66

SIV encephalopathy was studied in rhesus macaques early after intracerebral (IC) or intravenous (IV) inoculation. Although SIV was detected in the brain of all IC-inoculated animals, the CNS showed moderate neuropathological changes. IV-inoculated animals presented a spectrum of brain changes ranging from perivascular infiltrates to multinucleated giant cells. CNS infection was detected as early as seven days post-IV-inoculation, mostly in a perivascular localization. Using combined immunohistochemistry and in situ hybridization, infected cells were shown to express macrophage markers.

http://www.ncbi.nlm.nih.gov/pubmed/1942006