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© Charles DAUGUET, Institut Pasteur
HIV particles
Publication : Neuropathology and applied neurobiology

Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuropathology and applied neurobiology - 01 Dec 1995

Boche D, Gray F, Chakrabarti L, Hurtrel M, Montagnier L, Hurtrel B

Link to Pubmed [PMID] – 8745243

Neuropathol. Appl. Neurobiol. 1995 Dec;21(6):535-9

To assess the susceptibility of resident microglia to simian immunodeficiency virus (SIV) infection, we analysed the brains of rhesus macaques after intracerebral (i.c.) inoculation of the virus into the central region at 7 days, 1, 2 and 3 months post-inoculation (p.i.). The brains of animals showed the same moderate neuropathological changes in central, frontal and parietal regions of the brain, characterized by gliosis, microglial nodules, perivascular infiltrates and occasional white matter pallor and similar low numbers of infected cells detected by in situ hybridization. These results, showing that i.c. inoculation did not lead to preferential infection of brain tissue, even near the inoculation point at 7 days p.i., provide evidence for the low susceptibility of resident microglia to SIV replication during the early stages of infection.

http://www.ncbi.nlm.nih.gov/pubmed/8745243