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© Charles DAUGUET, Institut Pasteur
HIV particles
Publication : Current opinion in immunology

Immune mechanisms of HIV control

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 01 Aug 2010

Chakrabarti LA, Simon V

Link to Pubmed [PMID] – 20650621

Curr. Opin. Immunol. 2010 Aug;22(4):488-96

HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.

http://www.ncbi.nlm.nih.gov/pubmed/20650621