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© Charles DAUGUET, Institut Pasteur
HIV particles
Project

Characterization of the TCR signature induced by candidate HIV vaccines

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
02
Jan 2015
Ending Date
30
Nov 2020
Status
Ongoing
Members
1
Structures
1

About

The project aims at determining whether candidate HIV DNA vaccines can induce the type of high sensitivity CD4+ T cell responses characteristic of naturally controlled HIV infection. The main objective will be to devise sensitive and high throughput assays to define the TCR molecular signature induced by candidate HIV vaccines. Systematic comparison with the repertoire of public TCR clonotypes amplified in HIV Controllers will provide a way to rapidly assess the quality of the vaccine response at the molecular level.