Timeline
Pedro Alzari
Head of Structure
05 Apr 2024
publication
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Read more13 Mar 2024
publication
Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.
Read more10 Nov 2023
event
CANCELLED – Structural features and Biology, leading to therapy of p185HER2/neu-EGFr transformed cells – Mark I. Greene
Read more02 Nov 2023
event
Understanding the roles of Wag31 in cell morphology and septum-to-pole transition in Corynebacteriales: from mechanisms to applications – PhD Defense
Read more07 Sep 2023
publication
Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.
Read more10 Aug 2023
publication
High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Read more13 Dec 2022
publication
FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.
Read more14 Oct 2022
event
Mechanistic insights into corynebacterial divisome complexes involved in cell septation – PhD Defense – Quentin Gaday
Read more30 Nov 2021
publication
Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.
Read more04 Jun 2021
publication
SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system
Read more09 Apr 2020
02 Apr 2020
publication
Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.
Read more11 Feb 2020
28 Jan 2020
publication
Unexpected electron spin density on the axial methionine ligand in Cu suggests its involvement in electron pathways
Read more05 Dec 2019
publication
High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur
Read more01 Nov 2019
publication
Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.
Read more07 Aug 2019
publication
Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for Cu assembly in Cytochrome c Oxidase
Read more26 Jun 2019
publication
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Read more07 May 2019
publication
Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
Read more01 May 2019
publication
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Read more23 Apr 2019
publication
Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor
Read more16 Mar 2019
publication
The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function
Read more10 Feb 2019
publication
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.
Read more07 Feb 2019
publication
Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity
Read more21 Dec 2018
publication
The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop
Read more31 Aug 2018
publication
The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase
Read more04 Aug 2018
publication
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Read more25 May 2017
publication
Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase
Read more17 May 2017
publication
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Read more29 Jan 2017
publication
The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.
Read more01 Oct 2016
publication
Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA
Read more28 Sep 2016
publication
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase
Read more01 Sep 2016
publication
Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.
Read more09 May 2016
publication
Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.
Read more20 Jan 2016
20 Jan 2016
06 Jan 2016
10 Dec 2015
publication
Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis
Read more02 Dec 2015
04 Sep 2015
03 Jul 2015
03 Jul 2015
03 Jul 2015
18 Jun 2015
publication
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Read more11 May 2015
25 Mar 2015
publication
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Read more17 Nov 2014
publication
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.
Read more24 Sep 2014
publication
Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
Read more10 Sep 2014
publication
A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase
Read more13 May 2014
publication
Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)
Read more25 Feb 2014
28 Jan 2014
publication
Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation
Read more18 Nov 2013
publication
Structure-function relationships of membrane-associated GT-B glycosyltransferases
Read more11 Jan 2013
publication
Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.
Read more03 Jan 2013
publication
Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus
Read more21 Sep 2012
publication
Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site
Read more25 May 2012
publication
Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria
Read more03 May 2012
publication
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Read more23 Nov 2011
publication
Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket
Read more30 Apr 2011
publication
Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity
Read more27 Aug 2010
publication
Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria
Read more13 Apr 2010
09 Oct 2009
publication
Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.
Read more04 Sep 2009
publication
Structural plasticity and catalysis regulation of a thermosensor histidine kinase
Read more30 Aug 2009
publication
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
Read more01 Jul 2009
publication
Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings
Read more11 Jun 2009
publication
Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis
Read more15 Apr 2009
20 Feb 2009
publication
Functional in vitro assembly of the integral membrane bacterial thermosensor DesK
Read more16 Jan 2009
publication
Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis
Read more24 Dec 2008
publication
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening
Read more01 Oct 2008
16 Sep 2008
publication
Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD
Read more15 Sep 2008
20 Feb 2008
publication
Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis
Read more01 Jan 2008
publication
Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1
Read more01 Nov 2007
publication
Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD
Read more01 Nov 2007
01 Oct 2007
14 Aug 2007
publication
Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.
Read more27 Jul 2007
publication
The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria
Read more19 Jul 2007
publication
Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis
Read more02 Jul 2007
publication
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site
Read more16 May 2007
publication
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria
Read more16 Jan 2007
publication
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1
Read more15 Dec 2006
publication
The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria
Read more15 Dec 2006
publication
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase
Read more16 Nov 2006
publication
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
Read more30 Sep 2006
publication
Structure of armadillo ACBP: a new member of the acyl-CoA-binding protein family
Read more19 Sep 2006
publication
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
Read more19 Sep 2006
publication
SPINE bioinformatics and data-management aspects of high-throughput structural biology
Read more19 Sep 2006
publication
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE
Read more15 Sep 2006
publication
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth
Read more24 Aug 2006
15 Aug 2006
publication
Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons
Read more10 Aug 2006
publication
Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi
Read more02 May 2006
publication
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Read more30 Jan 2006
publication
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase
Read more18 Nov 2005
publication
Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase
Read more19 Sep 2005
publication
Identification of the critical residues involved in peptidoglycan detection by Nod1
Read more29 Jul 2005
publication
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions
Read more10 May 2005
publication
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress
Read more22 Apr 2005
publication
Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis
Read more28 Jan 2005
14 Jan 2005
01 Nov 2004
01 Sep 2004
publication
Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus
Read more22 Jul 2004
publication
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation
Read more01 May 2004
publication
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase
Read more12 Dec 2003
01 Sep 2003
publication
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis
Read more25 Jun 2003
publication
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile
Read more21 Feb 2003
publication
Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens
Read more11 Feb 2003
27 Jan 2003
publication
Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis
Read more24 Jan 2003
publication
The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase
Read more01 Oct 2002
publication
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Read more28 Sep 2002
23 Aug 2002
12 Jul 2002
publication
The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome
Read more01 Jun 2002
01 Jun 2002
01 May 2002
publication
1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module
Read more26 Apr 2002
publication
Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli
Read more22 Mar 2002
publication
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis
Read more19 Mar 2002
publication
Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier
Read more01 Mar 2002
publication
Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate
Read more19 Feb 2002
publication
Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA
Read more19 Feb 2002
publication
Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity
Read more01 Jun 2001
01 Apr 2001
publication
Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity
Read more01 Mar 2001
publication
Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants
Read more01 Dec 2000
publication
Can isotype switch modulate antigen-binding affinity and influence clonal selection?
Read more18 Jul 2000
publication
Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity
Read more14 Jul 2000
publication
Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes
Read more01 Jun 2000
publication
Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen
Read more01 Mar 2000
publication
Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy
Read more01 Mar 2000
publication
Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds
Read more01 Feb 2000
publication
The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells
Read more01 Jan 2000
25 May 1999
publication
Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase
Read more01 Apr 1999
publication
Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine
Read more01 Apr 1999
publication
Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1
Read more15 Mar 1999
publication
Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis
Read more12 Feb 1999
18 Jan 1999
18 Aug 1998
publication
Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites
Read more01 May 1998
01 Jan 1998
publication
Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate
Read more01 Dec 1997
publication
The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition
Read more31 Oct 1997
01 Aug 1997
publication
Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment
Read more21 Jul 1997
publication
Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa
Read more14 Jul 1997
publication
The MBP fusion protein restores the activity of the first phosphatase domain of CD45
Read more01 Jul 1997
publication
Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2
Read more01 Feb 1997
publication
Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae
Read more15 Jan 1997
20 Dec 1996
publication
cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily
Read more01 Oct 1996
publication
Interleukin 2 and its receptors: recent advances and new immunological functions
Read more01 Jun 1996
publication
Subcloning of a DNA fragment encoding a single cohesin domain of the Clostridium thermocellum cellulosome-integrating protein CipA: purification, crystallization, and preliminary diffraction analysis of the encoded polypeptide
Read more01 May 1996
19 Apr 1996
publication
The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism
Read more15 Mar 1996
publication
The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum
Read more01 Mar 1996
publication
A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex
Read more01 Jan 1996
01 Dec 1995
publication
Conservative substitutions in the hydrophobic core of Rhodobacter sphaeroides thioredoxin produce distinct functional effects
Read more28 Jul 1995
publication
Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme
Read more01 Jul 1995
publication
A common protein fold and similar active site in two distinct families of beta-glycanases
Read more28 Apr 1995
publication
Multiple crystal forms of endoglucanase CelD: signal peptide residues modulate lattice formation
Read more28 Apr 1995
publication
Structural and functional analysis of the metal-binding sites of Clostridium thermocellum endoglucanase CelD
Read more01 Jan 1995
publication
Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis
Read more01 Oct 1994
publication
The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain
Read more01 Jun 1994
publication
Characterization of two crystal forms of Clostridium thermocellum endoglucanase CelC
Read more01 May 1994
29 Mar 1994
publication
Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily
Read more28 Jan 1994
publication
Crystallization and preliminary diffraction analysis of the catalytic domain of xylanase Z from Clostridium thermocellum
Read more01 Jan 1994
publication
Structural implications of somatic mutations during the immune response to 2-phenyloxazolone
Read more15 Aug 1993
publication
Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex
Read more20 Mar 1993
publication
Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen
Read more01 Feb 1993
publication
Crystallization, preliminary X-ray diffraction study, and crystal packing of a complex between anti-hen lysozyme antibody F9.13.7 and guinea-fowl lysozyme
Read more15 Oct 1992
publication
Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody
Read more01 Nov 1991
publication
The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU
Read more11 Oct 1991
publication
Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein
Read more29 Jul 1991
publication
Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin
Read more01 Dec 1990
publication
Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity
Read more01 Dec 1990
publication
Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response
Read more01 Nov 1990
publication
Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies
Read more12 Jun 1989
19 May 1989
publication
The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase
Read more01 Jan 1989
publication
Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group
Read more01 Jan 1988
20 Sep 1987
publication
Preliminary crystallographic study of a complex between an heteroclitic anti-hen egg-white lysozyme antibody and the heterologous antigen pheasant egg-white lysozyme
Read more20 Jun 1986
publication
Preliminary crystallographic study of the Fab fragment of a monoclonal antibody directed against a cobra cardiotoxin
Read more01 May 1986
publication