Timeline

Pedro Alzari

Head of Structure

18 Oct 2024

publication

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.

05 Apr 2024

publication

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

13 Mar 2024

publication

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

10 Nov 2023

event

CANCELLED – Structural features and Biology, leading to therapy of p185HER2/neu-EGFr transformed cells – Mark I. Greene

02 Nov 2023

event

Understanding the roles of Wag31 in cell morphology and septum-to-pole transition in Corynebacteriales: from mechanisms to applications – PhD Defense

07 Sep 2023

publication

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

10 Aug 2023

publication

High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.

13 Dec 2022

publication

FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.

14 Oct 2022

event

Mechanistic insights into corynebacterial divisome complexes involved in cell septation – PhD Defense – Quentin Gaday

30 Nov 2021

publication

Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.

04 Jun 2021

publication

SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system

09 Apr 2020

project

Molecular mechanisms of bacterial cell division

02 Apr 2020

publication

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.

11 Feb 2020

event

EMBO Workshop on Tuberculosis 2020 postponed to September 2022

28 Jan 2020

publication

Unexpected electron spin density on the axial methionine ligand in Cu suggests its involvement in electron pathways

05 Dec 2019

publication

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

01 Nov 2019

publication

Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.

07 Aug 2019

publication

Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for Cu assembly in Cytochrome c Oxidase

26 Jun 2019

publication

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

07 May 2019

publication

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

01 May 2019

publication

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

23 Apr 2019

publication

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor

16 Mar 2019

publication

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function

10 Feb 2019

publication

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.

07 Feb 2019

publication

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

21 Dec 2018

publication

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

31 Aug 2018

publication

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

04 Aug 2018

publication

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

25 May 2017

publication

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

17 May 2017

publication

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

29 Jan 2017

publication

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

01 Oct 2016

publication

Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA

28 Sep 2016

publication

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

01 Sep 2016

publication

Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

09 May 2016

publication

Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.

20 Jan 2016

project

MM4TB

20 Jan 2016

project

SUPERCPLX

06 Jan 2016

news

The pullulanase secretion signal

10 Dec 2015

publication

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

02 Dec 2015

event

EMBO Conference Tuberculosis 2016

04 Sep 2015

project

Type II protein secretion mechanism

03 Jul 2015

project

Integrative structural studies of Corynebacteriales (Mycobacterium tuberculosis and Corynebacterium glutamicum) DNA gyrase (type II topoisomerase)

03 Jul 2015

project

PknA/PknB in mycobacterial cell division

03 Jul 2015

project

Control of glutamate metabolism in mycobacteria

18 Jun 2015

publication

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

11 May 2015

team

Structural Microbiology

25 Mar 2015

publication

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

17 Nov 2014

publication

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

24 Sep 2014

publication

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

10 Sep 2014

publication

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

13 May 2014

publication

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)

25 Feb 2014

publication

Generation of a vector suite for protein solubility screening

28 Jan 2014

publication

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation

18 Nov 2013

publication

Structure-function relationships of membrane-associated GT-B glycosyltransferases

11 Jan 2013

publication

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.

03 Jan 2013

publication

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus

21 Sep 2012

publication

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site

25 May 2012

publication

Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria

03 May 2012

publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

23 Nov 2011

publication

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket

30 Apr 2011

publication

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity

27 Aug 2010

publication

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria

13 Apr 2010

publication

A novel role of malonyl-ACP in lipid homeostasis.

09 Oct 2009

publication

Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.

04 Sep 2009

publication

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

30 Aug 2009

publication

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

01 Jul 2009

publication

Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings

11 Jun 2009

publication

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis

15 Apr 2009

publication

Bacterial metabolism under FHA control.

20 Feb 2009

publication

Functional in vitro assembly of the integral membrane bacterial thermosensor DesK

16 Jan 2009

publication

Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

24 Dec 2008

publication

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

01 Oct 2008

publication

Structural insights into sialic acid enzymology

16 Sep 2008

publication

Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD

15 Sep 2008

publication

Rising standards for tuberculosis drug development

20 Feb 2008

publication

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis

01 Jan 2008

publication

Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1

01 Nov 2007

publication

Towards new tuberculosis drugs

01 Nov 2007

publication

Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD

01 Oct 2007

publication

The crystal structure of Trypanosoma cruzi arginine kinase

14 Aug 2007

publication

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

27 Jul 2007

publication

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

19 Jul 2007

publication

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis

02 Jul 2007

publication

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site

16 May 2007

publication

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

01 Feb 2007

publication

Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.

15 Dec 2006

publication

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria

15 Dec 2006

publication

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

16 Nov 2006

publication

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

30 Sep 2006

publication

Structure of armadillo ACBP: a new member of the acyl-CoA-binding protein family

19 Sep 2006

publication

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

19 Sep 2006

publication

SPINE bioinformatics and data-management aspects of high-throughput structural biology

19 Sep 2006

publication

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE

15 Sep 2006

publication

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

24 Aug 2006

publication

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

15 Aug 2006

publication

Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons

10 Aug 2006

publication

Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi

02 May 2006

publication

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

30 Jan 2006

publication

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

18 Nov 2005

publication

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase

19 Sep 2005

publication

Identification of the critical residues involved in peptidoglycan detection by Nod1

29 Jul 2005

publication

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions

10 May 2005

publication

Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

22 Apr 2005

publication

Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis

28 Jan 2005

publication

A sialidase mutant displaying trans-sialidase activity

14 Jan 2005

publication

Microbiology. TB–a new target, a new drug

01 Nov 2004

publication

First structural glimpse at a bacterial Ser/Thr protein phosphatase

01 Sep 2004

publication

Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus

22 Jul 2004

publication

Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation

01 May 2004

publication

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase

12 Dec 2003

publication

Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family

01 Sep 2003

publication

PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis

25 Jun 2003

publication

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

21 Feb 2003

publication

Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens

11 Feb 2003

publication

The crystal structure of a plant lectin in complex with the Tn antigen

27 Jan 2003

publication

Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis

24 Jan 2003

publication

The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase

01 Oct 2002

publication

The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

28 Sep 2002

publication

Physical estimation of triplet phases from two new proteins

23 Aug 2002

publication

Advantages of high-resolution phasing: MAD to atomic resolution

12 Jul 2002

publication

The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome

01 Jun 2002

publication

The crystal structure of the mouse apoptosis-inducing factor AIF

01 Jun 2002

publication

The trans-sialidase from the african trypanosome Trypanosoma brucei

01 May 2002

publication

1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module

26 Apr 2002

publication

Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli

22 Mar 2002

publication

Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis

19 Mar 2002

publication

Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier

01 Mar 2002

publication

Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate

19 Feb 2002

publication

Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA

19 Feb 2002

publication

Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity

01 Jun 2001

publication

Characterization of an IL-2 mimetic with therapeutic potential

01 Apr 2001

publication

Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity

01 Mar 2001

publication

Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants

01 Dec 2000

publication

Can isotype switch modulate antigen-binding affinity and influence clonal selection?

18 Jul 2000

publication

Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity

14 Jul 2000

publication

Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes

01 Jun 2000

publication

Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen

01 Mar 2000

publication

Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy

01 Mar 2000

publication

Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds

01 Feb 2000

publication

The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells

01 Jan 2000

publication

Structural basis of sialyltransferase activity in trypanosomal sialidases

25 May 1999

publication

Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase

01 Apr 1999

publication

Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine

01 Apr 1999

publication

Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1

15 Mar 1999

publication

Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis

12 Feb 1999

publication

Structure of catalase-A from Saccharomyces cerevisiae

18 Jan 1999

publication

Mitochondrial release of caspase-2 and -9 during the apoptotic process

18 Aug 1998

publication

Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites

01 May 1998

publication

The cellulosome of Clostridium thermocellum

01 Jan 1998

publication

Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate

01 Dec 1997

publication

The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition

31 Oct 1997

publication

The crystal structure of a type I cohesin domain at 1.7 A resolution

01 Aug 1997

publication

Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment

21 Jul 1997

publication

Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa

14 Jul 1997

publication

The MBP fusion protein restores the activity of the first phosphatase domain of CD45

01 Jul 1997

publication

Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2

01 Feb 1997

publication

Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae

15 Jan 1997

publication

Structural and affinity studies of IgM polyreactive natural autoantibodies

20 Dec 1996

publication

cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily

01 Oct 1996

publication

Interleukin 2 and its receptors: recent advances and new immunological functions

01 Jun 1996

publication

Subcloning of a DNA fragment encoding a single cohesin domain of the Clostridium thermocellum cellulosome-integrating protein CipA: purification, crystallization, and preliminary diffraction analysis of the encoded polypeptide

01 May 1996

publication

Crystallization of a family 8 cellulase from Clostridium thermocellum

19 Apr 1996

publication

The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism

15 Mar 1996

publication

The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum

01 Mar 1996

publication

A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex

01 Jan 1996

publication

Crystallographic studies of antigen-antibody interactions

01 Dec 1995

publication

Conservative substitutions in the hydrophobic core of Rhodobacter sphaeroides thioredoxin produce distinct functional effects

28 Jul 1995

publication

Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme

01 Jul 1995

publication

A common protein fold and similar active site in two distinct families of beta-glycanases

28 Apr 1995

publication

Structural and functional analysis of the metal-binding sites of Clostridium thermocellum endoglucanase CelD

28 Apr 1995

publication

Multiple crystal forms of endoglucanase CelD: signal peptide residues modulate lattice formation

01 Jan 1995

publication

Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis

01 Oct 1994

publication

The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain

01 Jun 1994

publication

Characterization of two crystal forms of Clostridium thermocellum endoglucanase CelC

01 May 1994

publication

Crystal structures of pheasant and guinea fowl egg-white lysozymes

29 Mar 1994

publication

Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily

28 Jan 1994

publication

Crystallization and preliminary diffraction analysis of the catalytic domain of xylanase Z from Clostridium thermocellum

01 Jan 1994

publication

Structural implications of somatic mutations during the immune response to 2-phenyloxazolone

15 Aug 1993

publication

Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex

20 Mar 1993

publication

Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen

01 Feb 1993

publication

Crystallization, preliminary X-ray diffraction study, and crystal packing of a complex between anti-hen lysozyme antibody F9.13.7 and guinea-fowl lysozyme

15 Oct 1992

publication

Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody

01 Nov 1991

publication

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

11 Oct 1991

publication

Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein

29 Jul 1991

publication

Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin

01 Dec 1990

publication

Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response

01 Dec 1990

publication

Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity

01 Nov 1990

publication

Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies

12 Jun 1989

publication

Studies of structure and specificity of some antigen-antibody complexes

19 May 1989

publication

The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase

01 Jan 1989

publication

Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group

01 Jan 1988

publication

Three-dimensional structure of antibodies

20 Sep 1987

publication

Preliminary crystallographic study of a complex between an heteroclitic anti-hen egg-white lysozyme antibody and the heterologous antigen pheasant egg-white lysozyme

20 Jun 1986

publication

Preliminary crystallographic study of the Fab fragment of a monoclonal antibody directed against a cobra cardiotoxin

01 May 1986

publication

A little guide for advanced search:

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.

CANCELLED – Structural features and Biology, leading to therapy of p185HER2/neu-EGFr transformed cells – Mark I. Greene

Understanding the roles of Wag31 in cell morphology and septum-to-pole transition in Corynebacteriales: from mechanisms to applications – PhD Defense

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.

FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.

Mechanistic insights into corynebacterial divisome complexes involved in cell septation – PhD Defense – Quentin Gaday

Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.

SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system

Molecular mechanisms of bacterial cell division

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.

EMBO Workshop on Tuberculosis 2020 postponed to September 2022

Unexpected electron spin density on the axial methionine ligand in Cu suggests its involvement in electron pathways

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.

Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for Cu assembly in Cytochrome c Oxidase

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.

MM4TB

SUPERCPLX

The pullulanase secretion signal

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

EMBO Conference Tuberculosis 2016

Type II protein secretion mechanism

Integrative structural studies of Corynebacteriales (Mycobacterium tuberculosis and Corynebacterium glutamicum) DNA gyrase (type II topoisomerase)

PknA/PknB in mycobacterial cell division

Control of glutamate metabolism in mycobacteria

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Structural Microbiology

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)

Generation of a vector suite for protein solubility screening

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation

Structure-function relationships of membrane-associated GT-B glycosyltransferases

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site

Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria

A novel role of malonyl-ACP in lipid homeostasis.

Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis

Bacterial metabolism under FHA control.

Functional in vitro assembly of the integral membrane bacterial thermosensor DesK

Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Structural insights into sialic acid enzymology

Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD

Rising standards for tuberculosis drug development

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis

Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1

Towards new tuberculosis drugs

Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD