Timeline

Pedro Alzari
Head of Structure
07 May 2019
publication

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling

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25 Apr 2019
publication

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases

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23 Apr 2019
publication

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor

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16 Mar 2019
publication

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function

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07 Feb 2019
publication

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

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21 Dec 2018
publication

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

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26 Sep 2018
publication

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach

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31 Aug 2018
publication

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

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04 Aug 2018
publication

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

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25 May 2017
publication

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

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17 May 2017
publication

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

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29 Jan 2017
publication

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation

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01 Oct 2016
publication

Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA

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28 Sep 2016
publication

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

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01 Sep 2016
publication

Ser/Thr phosphorylation regulates the Fatty Acyl-AMP Ligase activity of FadD32, an essential enzyme in mycolic acid biosynthesis

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09 May 2016
publication

Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria

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20 Jan 2016
project

MM4TB

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20 Jan 2016
project

SUPERCPLX

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06 Jan 2016
news

The pullulanase secretion signal

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10 Dec 2015
publication

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis

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02 Dec 2015
event

EMBO Conference Tuberculosis 2016

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04 Sep 2015
project

Type II protein secretion mechanism

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03 Jul 2015
project

Structural studies of type II topoisomerases

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03 Jul 2015
project

PknA/PknB in mycobacterial cell division

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03 Jul 2015
project

Control of glutamate metabolism in mycobacteria

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18 Jun 2015
publication

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

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11 May 2015
team

Structural Microbiology

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07 May 2015
publication

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis

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25 Mar 2015
publication

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation

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17 Nov 2014
publication

Secondary structure reshuffling modulates glycosyltransferase function at the membrane

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24 Sep 2014
publication

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c

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10 Sep 2014
publication

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

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13 May 2014
publication

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)

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25 Feb 2014
publication

Generation of a vector suite for protein solubility screening

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01 Feb 2014
publication

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase)

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28 Jan 2014
publication

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation

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18 Nov 2013
publication

Structure-function relationships of membrane-associated GT-B glycosyltransferases

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08 Sep 2013
publication

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis

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20 Jun 2013
publication

Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center

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11 Jan 2013
publication

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins

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03 Jan 2013
publication

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus

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21 Sep 2012
publication

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site

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25 May 2012
publication

Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria

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03 May 2012
publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis

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23 Nov 2011
publication

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket

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26 Aug 2011
publication

Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism

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01 Jun 2011
publication

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation

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30 Apr 2011
publication

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity

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01 Sep 2010
publication

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

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27 Aug 2010
publication

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria

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13 Apr 2010
publication

A novel role of malonyl-ACP in lipid homeostasis

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15 Feb 2010
publication

Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria

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09 Oct 2009
publication

Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator

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18 Sep 2009
publication

Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria

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04 Sep 2009
publication

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

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30 Aug 2009
publication

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

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01 Jul 2009
publication

Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings

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11 Jun 2009
publication

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis

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15 Apr 2009
publication

Bacterial metabolism under FHA control

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20 Feb 2009
publication

Functional in vitro assembly of the integral membrane bacterial thermosensor DesK

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16 Jan 2009
publication

Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

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27 Dec 2008
publication

The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling

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24 Dec 2008
publication

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

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17 Oct 2008
publication

Regulation of glutamate metabolism by protein kinases in mycobacteria

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01 Oct 2008
publication

Structural insights into sialic acid enzymology

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16 Sep 2008
publication

Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD

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15 Sep 2008
publication

Rising standards for tuberculosis drug development

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20 Feb 2008
publication

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis

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01 Jan 2008
publication

Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1

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01 Nov 2007
publication

Towards new tuberculosis drugs

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01 Nov 2007
publication

Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD

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02 Oct 2007
publication

Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases

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01 Oct 2007
publication

The crystal structure of Trypanosoma cruzi arginine kinase

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14 Aug 2007
publication

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

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27 Jul 2007
publication

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

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19 Jul 2007
publication

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis

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02 Jul 2007
publication

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site

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01 Jul 2007
publication

Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme

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16 May 2007
publication

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

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16 Jan 2007
publication

Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1

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15 Dec 2006
publication

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria

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15 Dec 2006
publication

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

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16 Nov 2006
publication

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

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30 Sep 2006
publication

Structure of armadillo ACBP: a new member of the acyl-CoA-binding protein family

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19 Sep 2006
publication

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE

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19 Sep 2006
publication

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

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19 Sep 2006
publication

SPINE bioinformatics and data-management aspects of high-throughput structural biology

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15 Sep 2006
publication

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

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24 Aug 2006
publication

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

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15 Aug 2006
publication

Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons

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10 Aug 2006
publication

Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi

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02 May 2006
publication

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer

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27 Apr 2006
publication

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria

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30 Jan 2006
publication

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

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18 Nov 2005
publication

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase

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19 Sep 2005
publication

Identification of the critical residues involved in peptidoglycan detection by Nod1

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01 Aug 2005
publication

Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases

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29 Jul 2005
publication

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions

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10 May 2005
publication

Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

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22 Apr 2005
publication

Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis

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28 Jan 2005
publication

A sialidase mutant displaying trans-sialidase activity

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14 Jan 2005
publication

Microbiology. TB–a new target, a new drug

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01 Nov 2004
publication

First structural glimpse at a bacterial Ser/Thr protein phosphatase

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01 Sep 2004
publication

Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus

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22 Jul 2004
publication

Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation

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01 May 2004
publication

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase

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12 Dec 2003
publication

Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family

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01 Sep 2003
publication

PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis

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25 Jun 2003
publication

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

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21 Feb 2003
publication

Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens

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11 Feb 2003
publication

The crystal structure of a plant lectin in complex with the Tn antigen

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27 Jan 2003
publication

Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis

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24 Jan 2003
publication

The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase

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01 Oct 2002
publication

The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

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28 Sep 2002
publication

Physical estimation of triplet phases from two new proteins

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23 Aug 2002
publication

Advantages of high-resolution phasing: MAD to atomic resolution

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12 Jul 2002
publication

The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome

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01 Jun 2002
publication

The trans-sialidase from the african trypanosome Trypanosoma brucei

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01 Jun 2002
publication

The crystal structure of the mouse apoptosis-inducing factor AIF

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01 May 2002
publication

1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module

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26 Apr 2002
publication

Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli

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22 Mar 2002
publication

Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis

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19 Mar 2002
publication

Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier

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01 Mar 2002
publication

Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate

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19 Feb 2002
publication

Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA

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19 Feb 2002
publication

Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity

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01 Jun 2001
publication

Characterization of an IL-2 mimetic with therapeutic potential

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01 Apr 2001
publication

Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity

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01 Mar 2001
publication

Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants

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01 Dec 2000
publication

Can isotype switch modulate antigen-binding affinity and influence clonal selection?

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18 Jul 2000
publication

Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity

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14 Jul 2000
publication

Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes

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01 Jun 2000
publication

Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen

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01 Mar 2000
publication

Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy

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01 Mar 2000
publication

Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds

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01 Feb 2000
publication

The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells

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01 Jan 2000
publication

Structural basis of sialyltransferase activity in trypanosomal sialidases

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25 May 1999
publication

Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase

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01 Apr 1999
publication

Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine

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01 Apr 1999
publication

Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1

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15 Mar 1999
publication

Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis

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12 Feb 1999
publication

Structure of catalase-A from Saccharomyces cerevisiae

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18 Jan 1999
publication

Mitochondrial release of caspase-2 and -9 during the apoptotic process

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18 Aug 1998
publication

Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites

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01 May 1998
publication

The cellulosome of Clostridium thermocellum

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01 Jan 1998
publication

Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate

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01 Dec 1997
publication

The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition

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31 Oct 1997
publication

The crystal structure of a type I cohesin domain at 1.7 A resolution

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01 Aug 1997
publication

Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment

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21 Jul 1997
publication

Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa

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14 Jul 1997
publication

The MBP fusion protein restores the activity of the first phosphatase domain of CD45

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01 Jul 1997
publication

Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2

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01 Feb 1997
publication

Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae

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15 Jan 1997
publication

Structural and affinity studies of IgM polyreactive natural autoantibodies

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20 Dec 1996
publication

cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily

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01 Oct 1996
publication

Interleukin 2 and its receptors: recent advances and new immunological functions

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01 Jun 1996
publication

Subcloning of a DNA fragment encoding a single cohesin domain of the Clostridium thermocellum cellulosome-integrating protein CipA: purification, crystallization, and preliminary diffraction analysis of the encoded polypeptide

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01 May 1996
publication

Crystallization of a family 8 cellulase from Clostridium thermocellum

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19 Apr 1996
publication

The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism

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15 Mar 1996
publication

The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum

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01 Mar 1996
publication

A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex

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01 Jan 1996
publication

Crystallographic studies of antigen-antibody interactions

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01 Dec 1995
publication

Conservative substitutions in the hydrophobic core of Rhodobacter sphaeroides thioredoxin produce distinct functional effects

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28 Jul 1995
publication

Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme

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01 Jul 1995
publication

A common protein fold and similar active site in two distinct families of beta-glycanases

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28 Apr 1995
publication

Multiple crystal forms of endoglucanase CelD: signal peptide residues modulate lattice formation

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28 Apr 1995
publication

Structural and functional analysis of the metal-binding sites of Clostridium thermocellum endoglucanase CelD

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01 Jan 1995
publication

Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis

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01 Oct 1994
publication

The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain

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01 Jun 1994
publication

Characterization of two crystal forms of Clostridium thermocellum endoglucanase CelC

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01 May 1994
publication

Crystal structures of pheasant and guinea fowl egg-white lysozymes

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29 Mar 1994
publication

Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily

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28 Jan 1994
publication

Crystallization and preliminary diffraction analysis of the catalytic domain of xylanase Z from Clostridium thermocellum

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01 Jan 1994
publication

Structural implications of somatic mutations during the immune response to 2-phenyloxazolone

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15 Aug 1993
publication

Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex

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20 Mar 1993
publication

Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen

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01 Feb 1993
publication

Crystallization, preliminary X-ray diffraction study, and crystal packing of a complex between anti-hen lysozyme antibody F9.13.7 and guinea-fowl lysozyme

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15 Oct 1992
publication

Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody

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01 Nov 1991
publication

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

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11 Oct 1991
publication

Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein

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29 Jul 1991
publication

Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin

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01 Dec 1990
publication

Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity

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01 Dec 1990
publication

Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response

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01 Nov 1990
publication

Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies

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12 Jun 1989
publication

Studies of structure and specificity of some antigen-antibody complexes

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19 May 1989
publication

The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase

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01 Jan 1989
publication

Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group

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01 Jan 1988
publication

Three-dimensional structure of antibodies

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20 Sep 1987
publication

Preliminary crystallographic study of a complex between an heteroclitic anti-hen egg-white lysozyme antibody and the heterologous antigen pheasant egg-white lysozyme

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20 Jun 1986
publication

Preliminary crystallographic study of the Fab fragment of a monoclonal antibody directed against a cobra cardiotoxin

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01 May 1986
publication

Crystallization and preliminary X-ray diffraction study of an endoglucanase from Clostridium thermocellum

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