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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : FEBS letters

The crystal structure of a plant lectin in complex with the Tn antigen

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 11 Feb 2003

Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM

Link to Pubmed [PMID] – 12586347

FEBS Lett. 2003 Feb;536(1-3):106-10

The structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc-O-Ser), was determined at 2.7 A resolution. The N-acetylgalactoside moiety of the ligand binds to the primary combining site of VVLB4 in a similar way as observed for other Gal/GalNAc-specific plant lectins. The amino acid moiety of the Tn antigen is largely exposed to the solvent and makes few contacts with the protein. The structure of the complex provides a framework to understand the differences in the strength of VVLB4 binding to different sugars and emphasizes the role of a single protein residue, Tyr127, as a structural determinant of Tn-binding specificity.

http://www.ncbi.nlm.nih.gov/pubmed/12586347