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© Institut Pasteur
Cells infected for 24 hrs with C. Trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted out the inclusion into the host cytoplasm id labelled in red.
Publication : Current opinion in chemical biology

Structural insights into sialic acid enzymology

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in chemical biology - 01 Oct 2008

Buschiazzo A, Alzari PM

Link to Pubmed [PMID] – 18625334

Curr Opin Chem Biol 2008 Oct;12(5):565-72

Sialic acids are a diverse family of negatively charged sugars that play essential biological roles. Their presence and relative abundance in different cells is ultimately regulated by the concerted action of a large set of enzymes. In this review, we focus on the most recent advances on the enzymes that govern sialic acid metabolism, with emphasis on structural work. Major progress has been made in dissecting the catalytic mechanism of sialidases, revealing a modified scenario of the typical glycosidase ping-pong mechanism. Similarly, X-ray structures of sialyltransferases uncover significant variations of formerly known glycosyltransferase foldings. Both sialidases and sialyltransferases seem to tell us that sialic acid-handling enzymes have evolved important modifications related to the distinctive features of sialic acid itself.

http://www.ncbi.nlm.nih.gov/pubmed/18625334