Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Institut Pasteur
Cells infected for 24 hrs with C. Trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted out the inclusion into the host cytoplasm id labelled in red.
Publication : European journal of immunology

Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Jul 2009

Boucontet L, Grana M, Alzari PM, Pereira P

Link to Pubmed [PMID] – 19585514

Eur. J. Immunol. 2009 Jul;39(7):1937-46

We investigated the ability of the most common TCR-gamma and delta chains to express on the cell surface. Vgamma1Cgamma4 and Vgamma7Cgamma1 chains paired with all TCR-delta chains tested, whereas Vgamma4Cgamma1 chains were found with Vdelta4 and Vdelta5, but not with Vdelta2 or Vdelta6 chains, and Vgamma2Cgamma2 chains were expressed only with Vdelta5. Mapping studies showed that up to four polymorphic residues influence the different co-expressions of Vgamma1 and Vgamma2 chains with Vdelta chains. Unexpectedly, these residues are not located in the canonical gamma/delta interface, but in the outer part of the gammadelta TCR complex exposed to the solvent. Expression of functional Vdelta4 or Vdelta6 chains in Vgamma2/Vdelta5(+) cells or of functional Vgamma2Cgamma2 in Vgamma1(+) cells reduced cell-surface expression of the gammadelta TCR. Taken together, these data show that (i) the Vgamma/Vdelta repertoire of mouse gammadelta T cells is reduced by physical constraints in their associations. (ii) Lack of Vgamma2/Vdelta expression is due to the formation of aberrant TCR complexes, rather than to an intrinsic inability of the chains to pair and (iii) despite not being expressed at the cell surface, the presence of a functionally rearranged Vgamma2 chain in gammadelta T cells results in reduced TCR levels.