Groupe: Nicolas Wolff

Présentation

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Membres

Nicolas Wolff

Chef(fe) de Groupe

Responsable

Célia Caillet-Saguy

Chercheur(euse) Permanent(e)

Mariano Genera

Etudiant(e) en thèse

Yanlei Zhu

Etudiant(e) en thèse

Emilie (de La Llave) Giraud

Post-doctorant(e)

Baptiste COLCOMBET-CAZENAVE

Etudiant(e) en thèse

Tiziana Lo Campo

Etudiant(e)

Anciens Membres

Florence Cordier

Virginie Girault

Florent Delhommel

Damien Samson

Juan Ramon Ramirez Ramos

Alain Chaffotte

Projets

project

En cours

4 Membres

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

Nicolas Wolff (PI)

Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]

project

En cours

4 Membres

Rabies virus neuronal infection

Nicolas Wolff (PI)

We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]

Financements

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Publications

Télécharger

• 2017
  Delhommel F, Cordier F, Bardiaux B, Bouvier G, Colcombet-Cazenave B, Brier S, Raynal B, Nouaille S, Bahloul A, Chamot-Rooke J, Nilges M, Petit C, Wolff N, Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure 2017 Nov;25(11):1645-1656.e5.
• 2017
  Caillet-Saguy C, Toto A, Guerois R, Maisonneuve P, di Silvio E, Sawyer K, Gianni S, Wolff N, Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains, Sci Rep 2017 Aug;7(1):7875.
• 2017
  Bahloul A, Pepermans E, Raynal B, Wolff N, Cordier F, England P, Nouaille S, Baron B, El-Amraoui A, Hardelin JP, Durand D, Petit C, Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery, FEBS Lett. 2017 08;591(15):2299-2310.
• 2016
  Delhommel F, Wolff N, Cordier F, (1)H, (13)C and (15)N backbone resonance assignments and dynamic properties of the PDZ tandem of Whirlin, Biomol NMR Assign 2016 Oct;10(2):361-5.
• 2016
  Maisonneuve P, Caillet-Saguy C, Vaney MC, Bibi-Zainab E, Sawyer K, Raynal B, Haouz A, Delepierre M, Lafon M, Cordier F, Wolff N, Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ, J. Biol. Chem. 2016 08;291(32):16699-708.
• 2015
  Vincentelli R, Luck K, Poirson J, Polanowska J, Abdat J, Blémont M, Turchetto J, Iv F, Ricquier K, Straub ML, Forster A, Cassonnet P, Borg JP, Jacob Y, Masson M, Nominé Y, Reboul J, Wolff N, Charbonnier S, Travé G, Quantifying domain-ligand affinities and specificities by high-throughput holdup assay, Nat. Methods 2015 Aug;12(8):787-93.
• 2015
  Delhommel F, Chaffotte A, Terrien E, Raynal B, Buc H, Delepierre M, Cordier F, Wolff N, Deciphering the unconventional peptide binding to the PDZ domain of MAST2, Biochem. J. 2015 Jul;469(1):159-68.
• 2015
  Caillet-Saguy C, Maisonneuve P, Delhommel F, Terrien E, Babault N, Lafon M, Cordier F, Wolff N, Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus, Prog. Biophys. Mol. Biol. 2015 Oct;119(1):53-9.
• 2014
  Cordier F, Chaffotte A, Wolff N, Quantitative and dynamic analysis of PTEN phosphorylation by NMR, Methods 2015 May;77-78:82-91.
• 2014
  Maisonneuve P, Caillet-Saguy C, Raynal B, Gilquin B, Chaffotte A, Pérez J, Zinn-Justin S, Delepierre M, Buc H, Cordier F, Wolff N, Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain, FEBS J. 2014 Nov;281(21):4852-65.
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Publié le: 16 Jul 2015 • Modifié le: 07 Sep 2018