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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Feb 2013
Ending Date
01
Feb 2040
Status
Ongoing
Members
5
Structures
2

About

Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells and have the capacity to interact with each other through PDZ domains and PBM. We aim at characterizing the organization of submembrane complexes involved in the mechano-electrical transduction machinery and in the inter-stereocilia links (PTR 483 2014-2016; ITN H2020 2016-2019). We are deciphering the functional and structural role of the PDZ containing protein Whirlin, a key Usher protein. This large protein of about 1000 residues is composed 6 protein-protein interaction domains. We have recently produced and characterized several mono- and multi-domain constructs of Whirlin. Combining NMR, SAXS and SPR experiments, we have shown that some domains of Whirlin are associated as supramodules modulating the affinity and specificity for PDZ ligands, proteins and lipids.