- We use biophysical experimental techniques such as crystallography and cryo-EM to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling (cell-cell communications).
- We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
- We also try to better understand the electrostatics of macromolecules and their interaction with the solvent and ligands, in order to be able to predict their binding properties.
- The massive sequence data of related homologues is analyzed by by methods derived from statistical thermodynamics
- Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
- More details can be found at http://lorentz.dynstr.pasteur.fr (internal users) or at (external users) http://www.dynstr.pasteur.fr
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Connections
About
Members
Groups
Group
DNA replication group
Ludovic Sauguet
Former Members
2000
2000
Name
Position
2005
2006
Erik Lindahl
Post-doc
2005
2010
Félix Romain
Ingénieur
2005
2008
Jérémie Piton
PhD Student
2005
2008
Cyril Azuara
PhD Student
2008
2014
Jerome Gouge
PhD Student
2008
2012
Hugues Nury
Post-doc
2009
2010
Claudine Mayer
Prof. Paris Cité
2010
2010
Dennis Ptchelkine
Post-doc
2012
2016
Frederic Poitevin
PhD Student
2014
2020
Zaineb Fourati-Kammoun
Post-doc
2015
2020
Frédéric Poitevin
Post-doc
2015
2020
Filippo Romoli
Post-doc
2015
2020
Danièle Sinnaya
Administrative Staff
2015
2020
Irina Volahasina Randrianjatovo-Gbalou
Post-doc
2015
2020
Pierre Raia
PhD Student
2015
2020
Jérôme Loc’h
Post-doc
2015
2020
Haidai Hu
PhD Student
2015
2020
Victoire Prat
Undergraduate Student
2016
2020
Thomas Ybert
Post-doc
2017
2021
Dariusz Czernecki
PhD Student
2018
2022
Clement Madru
Post-doc
2018
2021
Camille Samson
Post-doc
2020
2024
Antonin Nourisson
PhD Student
2021
2024
Rémi Sieskind
Post-doc
2022
2024
Isciane Commenge
Ingénieur
2023
2023
Milena Milovanovic
Master Student
Show all
Projects
Transversal Project
Software
Fundings
Publications
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2024Crystal structures of monomeric BsmI restriction endonuclease reveal a coordinated action of its two distinct active sites to sequentially cleave the two DNA strands, Communications Biology.
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2024Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor, 2024.
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2024Template-Independent Enzymatic RNA Synthesis, 2024.
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2024Vestibular Modulation by Stimulant Derivatives in a Pentameric Ligand-Gated Ion Channel, 2024.
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2023Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases., Nat Commun 2023 Dec; 14(1): 8306.
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2023Analyzing the Geometry and Dynamics of Viral Structures: A Review of Computational Approaches Based on Alpha Shape Theory, Normal Mode Analysis, and Poisson–Boltzmann Theories, Viruses 2023, 15, 1366.
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2023DNA-binding mechanism and evolution of replication protein A., Nat Commun 2023 Apr; 14(1): 2326.
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2023Reclassification of family A DNA polymerases reveals novel functional subfamilies and distinctive structural features, Nucleic Acids Research 2023 May 22;51(9):4488-4507.
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2023Computing the Gromov-Wasserstein Distance between Two Surface Meshes Using Optimal Transport, Algorithms 2023, 16, 131.
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2021Structural dynamics and determinants of 2-aminoadenine specificity in DNA polymerase DpoZ of vibriophage ϕVC8., Nucleic Acids Res 2021 Nov; 49(20): 11974-11985.
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+View full list of publications
Contact
Marie de Tarragon Phone: Ext. 86 96 Email: marie.de-tarragon@pasteur.fr Address
Architecture and Dynamics of Biological Macromolecules |