Tool
Medicinal Chemistry [61]
Project
Inhibitors of Pseudomonas aeruginosa IMPDH
Sophie Vichier-Guerre • Hélène Munier-Lehmann
Project
Binding mode of promising antituberculosis clinical compounds to their bacterial target
Nadia Izadi-Pruneyre
Project
Inhibitors of TMPK from Mycobacterium tuberculosis
Hélène Munier-Lehmann • Sylvie Pochet
Project
Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions
Project
Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Sylvie Pochet • Pierre Alexandr Kaminski
Project
Nanotherapeutics for Antibiotic Resistant Emerging Bacterial pathogens
Brigitte Gicquel
Project
Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)
Project
Alkoxypyrazoles, new chemical entities
Group
Group: Biochemistry and chemobiology
Hélène Munier-Lehmann
2015
Publication
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
Journal of medicinal chemistry
Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL
Platform
Chemogenomic and Biological Screening Platform (PF-CCB)
Fabrice Agou
Laboratory
Trypanosomatids Infectious Processes
Paola Minoprio
Laboratory
Chemistry of Biomolecules
Laurence Mulard
Laboratory
Integrative Neurobiology of Cholinergic Systems
Uwe Maskos
Full Professor
Permanent Researcher
Olivier Dussurget
Group : Bacterial Pathogenesis and Antibacterial Agents
In a globalized world heading for a post-antibiotic era, refined understanding of human, animal and environmental interactions with pathogenic bacteria is of utmost importance. The primary aim of our research is to discover bacterial […]