In a globalized world heading for a post-antibiotic era, refined understanding of human, animal and environmental interactions with pathogenic bacteria is of utmost importance. The primary aim of our research is to discover bacterial and host factors playing a critical role in the pathogenesis of infectious diseases and whose characterization will help develop innovative diagnostic and therapeutic strategies. We take a combination of multiscale models and systems biology approaches to investigate host-pathogen interactions, identify biomarkers and targets, and ultimately design novel infection control tools through crossdisciplinary collaborations. One major focus is to decipher mechanisms of systemic infection evolved by Yersinia pestisand other important human pathogenic bacteria.
NOVOPLASM – Novel perspective for cold plasma application in the treatment of severe and infected burn wounds
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Clinical and bacterial determinants of Yersinia pestis bacteremia
Yersinia pestis is the highly infectious Gram-negative bacterium that causes plague, which is responsible for the most devastating pandemics in human history. Three main clinical forms include the most common bubonic plague resulting from the […]
Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer
CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Inhibitors of bacterial NAD kinases
NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]
2023Yersiniomics, a Multi-Omics Interactive Database for Yersinia Species., Microbiol Spectr 2023 Feb; (): e0382622.
2023Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria., Eur J Med Chem 2023 Jan; 246(): 114941.
2022The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization., Gut Microbes 2022 ; 14(1): 2121577.
2022NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes., Elife 2022 Jun; 11(): .
2022Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics., Microbes Infect 2019 ; 21(5-6): 202-212.
2022Upward trend for “Microbes and Infection”., Microbes Infect 2022 ; 24(8): 105057.
2021Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner., Proc Natl Acad Sci U S A 2021 Oct; 118(40): .
2021Cold Atmospheric Plasma Promotes Killing of Staphylococcus aureus by Macrophages., mSphere 2021 Jun; 6(3): e0021721.
2020New Chemical Probe Targeting Bacterial NAD Kinase., Molecules 2020 Oct; 25(21): .
2020Three decades of listeriology through the prism of technological advances., Cell Microbiol 2020 Apr; 22(4): e13183.
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