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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique

About

In a globalized world heading for a post-antibiotic era, refined understanding of human, animal and environmental interactions with pathogenic bacteria is of utmost importance. The primary aim of our research is to discover bacterial and host factors playing a critical role in the pathogenesis of infectious diseases and whose characterization will help develop innovative diagnostic and therapeutic strategies. We take a combination of multiscale models and systems biology approaches to investigate host-pathogen interactions, identify biomarkers and targets, and ultimately design novel infection control tools through crossdisciplinary collaborations. One major focus is to decipher mechanisms of systemic infection evolved by Yersinia pestisand other important human pathogenic bacteria.

Projects

Project
Not started
3 Members

NOVOPLASM – Novel perspective for cold plasma application in the treatment of severe and infected burn wounds

Nadira Frescaline (PI)

Sorry, this entry is only available in French.
Project
Ongoing
2 Members

Clinical and bacterial determinants of Yersinia pestis bacteremia

Olivier Dussurget (PI)

Yersinia pestis is the highly infectious Gram-negative bacterium that causes plague, which is responsible for the most devastating pandemics in human history. Three main clinical forms include the most common bubonic plague resulting from the […]
Project
Ongoing
6 Members

Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Project
Ongoing
8 Members

Inhibitors of bacterial NAD kinases

Sylvie Pochet (PI)

NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]

Publications

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