In a globalized world heading for a post-antibiotic era, refined understanding of human, animal and environmental interactions with pathogenic bacteria is of utmost importance. The primary aim of our research is to discover bacterial and host factors playing a critical role in the pathogenesis of infectious diseases and whose characterization will help develop innovative diagnostic and therapeutic strategies. We take a combination of multiscale models and systems biology approaches to investigate host-pathogen interactions, identify biomarkers and targets, and ultimately design novel infection control tools through crossdisciplinary collaborations. One major focus is to decipher mechanisms of systemic infection evolved by Yersinia pestisand other important human pathogenic bacteria.
NOVOPLASM – Novel perspective for cold plasma application in the treatment of severe and infected burn wounds
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Clinical and bacterial determinants of Yersinia pestis bacteremia
Yersinia pestis is the highly infectious Gram-negative bacterium that causes plague, which is responsible for the most devastating pandemics in human history. Three main clinical forms include the most common bubonic plague resulting from the […]
Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer
CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Inhibitors of bacterial NAD kinases
NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]
2022NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes., Elife 2022 Jun; 11(): .
2021Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner., Proc Natl Acad Sci U S A 2021 10; 118(40): .
2021Cold Atmospheric Plasma Promotes Killing of Staphylococcus aureus by Macrophages., mSphere 2021 Jun; (): e0021721.
2020Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria., Front Cell Infect Microbiol 2020 ; 10(): 577559.
2020New Chemical Probe Targeting Bacterial NAD Kinase., Molecules 2020 Oct; 25(21): .
2020Three decades of listeriology through the prism of technological advances., Cell Microbiol 2020 04; 22(4): e13183.
2020From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus., ACS Infect Dis 2020 03; 6(3): 422-435.
2019Ubiquitination of Listeria Virulence Factor InlC Contributes to the Host Response to Infection., mBio 2019 12; 10(6): .
2019The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection., Nat Commun 2019 11; 10(1): 5383.
2019A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection., Cell Host Microbe 2019 11; 26(5): 691-701.e5.
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