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© Andreas Kühbacher, Edith Gouin, Jason Mercer, Mario Emmenlauer, Christophe Dehio, Pascale Cossart and Javier Pizarro-Cerda
Immunofluorescence and segmentation analysis of HeLa cells infected with Listeria monocytogenes. Cells were labelled with DAPI to mark DNA (blue), with phalloidin to mark actin (red) and with anti-Internalin C antibodies to identify infected cells (yellow). Nuclei and cytoplasms were segmented using the public image analysis software CellProfiler
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 02 May 2016

Quereda JJ, Dussurget O, Nahori MA, Ghozlane A, Volant S, Dillies MA, Regnault B, Kennedy S, Mondot S, Villoing B, Cossart P, Pizarro-Cerda J

Link to Pubmed [PMID] – 27140611

Proc. Natl. Acad. Sci. U.S.A. 2016 May;

Listeria monocytogenes is responsible for gastroenteritis in healthy individuals and for a severe invasive disease in immunocompromised patients. Among the three identified L. monocytogenes evolutionary lineages, lineage I strains are overrepresented in epidemic listeriosis outbreaks, but the mechanisms underlying the higher virulence potential of strains of this lineage remain elusive. Here, we demonstrate that Listeriolysin S (LLS), a virulence factor only present in a subset of lineage I strains, is a bacteriocin highly expressed in the intestine of orally infected mice that alters the host intestinal microbiota and promotes intestinal colonization by L. monocytogenes, as well as deeper organ infection. To our knowledge, these results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate modulation of host microbiota by L. monocytogenes epidemic strains to increased virulence.

http://www.ncbi.nlm.nih.gov/pubmed/27140611