In a globalized world heading for a post-antibiotic era, refined understanding of human, animal and environmental interactions with pathogenic bacteria is of utmost importance. The primary aim of our research is to discover bacterial and host factors playing a critical role in the pathogenesis of infectious diseases and whose characterization will help develop innovative diagnostic and therapeutic strategies. We take a combination of multiscale models and systems biology approaches to investigate host-pathogen interactions, identify biomarkers and targets, and ultimately design novel infection control tools through cross-disciplinary collaborations. One major focus is to decipher mechanisms of systemic infection evolved by Yersinia pestisand other important human pathogenic bacteria.
Members
Former Members
2000
2000
Name
Position
Océane Blaise
Alix Demians d'Archimbaud
Référente santé, Klein Blue, Paris
Clarisse Leseigneur
Post-doctorante, Institut Pasteur, Paris
Constance Duchesne
Ingénieure de recherche, L'Oréal, Saint-Ouen
Constance Porrini
Research and innovation manager, Eden Tech, Paris
Andrzej Prokop
Senior programmer, Astra Zeneca, Warsaw
Camille Aubry
Medical affairs advisor, LEO pharma, Maisons-Alfort
Céline Goulard
Chargée de communication, CEA, Saclay
Anastasia Saade
Chef de clinique, Rennes
Cristel Archambaud
Chargée de recherche, INRAE, Jouy-en-Josas
Transversal Project
Fundings
Partners
Publications
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2023Complete Genome Sequences of Bioluminescent Staphylococcus aureus Strains Xen31 and Xen36, Derived from Two Clinical Isolates., Microbiol Resour Announc 2023 Feb; (): e0002423.
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2023Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria., Eur J Med Chem 2023 Jan; 246(): 114941.
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2022The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization., Gut Microbes 2022 ; 14(1): 2121577.
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2022NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes., Elife 2022 Jun; 11(): .
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2022Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics., Microbes Infect 2019 ; 21(5-6): 202-212.
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2022Upward trend for “Microbes and Infection”., Microbes Infect 2022 ; 24(8): 105057.
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2022Danger signals in traumatic hemorrhagic shock and new lines for clinical applications., Front Physiol 2022 ; 13(): 999011.
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2021Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner., Proc Natl Acad Sci U S A 2021 Oct; 118(40): .
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2021Cold Atmospheric Plasma Promotes Killing of Staphylococcus aureus by Macrophages., mSphere 2021 Jun; 6(3): e0021721.
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2020Physical plasma therapy accelerates wound re-epithelialisation and enhances extracellular matrix formation in cutaneous skin grafts., J Pathol 2020 12; 252(4): 451-464.
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