In a globalized world heading for a post-antibiotic era, refined understanding of human, animal and environmental interactions with pathogenic bacteria is of utmost importance. The primary aim of our research is to discover bacterial and host factors playing a critical role in the pathogenesis of infectious diseases and whose characterization will help develop innovative diagnostic and therapeutic strategies. We take a combination of multiscale models and systems biology approaches to investigate host-pathogen interactions, identify biomarkers and targets, and ultimately design novel infection control tools through cross-disciplinary collaborations. One major focus is to decipher mechanisms of systemic infection evolved by Yersinia pestisand other important human pathogenic bacteria.
Members
Former Members
2000
2000
Name
Position
Alix Demians d'Archimbaud
Clarisse Leseigneur
Constance Duchesne
Constance Porrini
Andrzej Prokop
Camille Aubry
Céline Goulard
Anastasia Saade
Cristel Archambaud
Transversal Project
Fundings
Partners
Publications
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2022NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes., Elife 2022 Jun; 11(): .
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2021Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner., Proc Natl Acad Sci U S A 2021 10; 118(40): .
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2021Cold Atmospheric Plasma Promotes Killing of Staphylococcus aureus by Macrophages., mSphere 2021 Jun; (): e0021721.
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2020Physical plasma therapy accelerates wound re-epithelialisation and enhances extracellular matrix formation in cutaneous skin grafts., J Pathol 2020 12; 252(4): 451-464.
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2020Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria., Front Cell Infect Microbiol 2020 ; 10(): 577559.
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2020New Chemical Probe Targeting Bacterial NAD Kinase., Molecules 2020 Oct; 25(21): .
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2020A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft., J Vis Exp 2020 08; (162): .
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2020Three decades of listeriology through the prism of technological advances., Cell Microbiol 2020 04; 22(4): e13183.
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2020From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus., ACS Infect Dis 2020 03; 6(3): 422-435.
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2019Ubiquitination of Listeria Virulence Factor InlC Contributes to the Host Response to Infection., mBio 2019 12; 10(6): .
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